STOCK Atat1tm1.1Phep/Cnrm

Status

Available to order

EMMA IDEM:07148
Citation informationRRID:IMSR_EM:07148 

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International strain nameSTOCK Atat1tm1.1Phep/Cnrm
Alternative nameAtat1 Flx
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolAtat1tm1.1Phep
Gene/Transgene symbolAtat1

Information from provider

ProviderPaul Heppenstall
Provider affiliation Adriano Buzzati-Traverso Campus, EMBL Monterotondo
Genetic informationExons 1-6 of the Atat1 allele are flanked with loxP sites that enable conditional mutagenesis. FRT site is 3' of the 3' loxP site.
Phenotypic informationNo detected phenotypes.
References
  • αTAT1 is the major α-tubulin acetyltransferase in mice.;Kalebic Nereo, Sorrentino Simona, Perlas Emerald, Bolasco Giulia, Martinez Concepcion, Heppenstall Paul A, ;2013;Nature communications;4;1962; 23748901
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal cell morphology / MGI
  • abnormal dentate gyrus morphology / MGI
  • dilated lateral ventricles / MGI
  • reduced male fertility / MGI
  • decreased litter size / MGI
  • no abnormal phenotype detected / MGI
  • asthenozoospermia / MGI
  • oligozoospermia / MGI
  • increased thigmotaxis / MGI
  • decreased testis weight / MGI
  • decreased epididymis weight / MGI
  • behavior/neurological phenotype / MGI
  • hematopoietic system phenotype / MGI
  • teratozoospermia / MGI
  • abnormal cell physiology / MGI
  • abnormal male germ cell apoptosis / MGI
  • short sperm flagellum / MGI
  • abnormal sperm annulus morphology / MGI
  • mortality/aging / MGI
  • integument phenotype / MGI

Literature references

  • αTAT1 is the major α-tubulin acetyltransferase in mice.;Kalebic Nereo, Sorrentino Simona, Perlas Emerald, Bolasco Giulia, Martinez Concepcion, Heppenstall Paul A, ;2013;Nature communications;4;1962; 23748901

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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