129S2.Cg-Ago2tm1.1Doca/Cnrm

Status

Available to order

EMMA IDEM:07112
Citation informationRRID:IMSR_EM:07112 

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International strain name129S2.Cg-Ago2tm1.1Doca/Cnrm
Alternative name129S2/SvHsd - Ago2S388A
Strain typeTargeted Mutant Strains : Point mutation
Allele/Transgene symbolAgo2tm1.1Doca
Gene/Transgene symbolAgo2

Information from provider

ProviderDonal O'Carroll
Provider affiliationMouse Biology Unit, European Molecular Biology Laboratory
Genetic informationTwo point mutations in exon 10, converting Serine 388 in an Alanine residue. Residual LoxP site between exon 8 and 9 due to removal of neomycin resistance cassette.
Phenotypic informationHomozygous mice for the point mutation are born with subMendelian frequencies in this genetic background.
Breeding historyThe mice were backcrossed 9 times with 129S2/SvHsd mice from Harlan.
ReferencesNone available
Homozygous fertileyes
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • enlarged heart / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal placenta morphology / MGI
  • placental labyrinth hypoplasia / MGI
  • abnormal visceral yolk sac morphology / MGI
  • embryonic growth arrest / MGI
  • pericardial edema / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal proerythroblast morphology / MGI
  • decreased erythrocyte cell number / MGI
  • no phenotypic analysis / MGI
  • abnormal forebrain development / MGI
  • pallor / MGI
  • embryonic growth retardation / MGI
  • small placenta / MGI
  • cellular phenotype / MGI
  • neonatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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