- enlarged heart / MGI
- open neural tube / MGI
- wavy neural tube / MGI
- abnormal placenta morphology / MGI
- placental labyrinth hypoplasia / MGI
- abnormal visceral yolk sac morphology / MGI
- embryonic growth arrest / MGI
- pericardial edema / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal proerythroblast morphology / MGI
- decreased erythrocyte cell number / MGI
- no phenotypic analysis / MGI
- abnormal forebrain development / MGI
- pallor / MGI
- embryonic growth retardation / MGI
- small placenta / MGI
- cellular phenotype / MGI
- neonatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
B6NHsd.Cg-Ago2tm1.1Doca/Cnrm
Status | Available to order |
EMMA ID | EM:07111 |
International strain name | B6NHsd.Cg-Ago2tm1.1Doca/Cnrm |
Alternative name | Ago2S388A |
Strain type | Targeted Mutant Strains : Point mutation |
Allele/Transgene symbol | Ago2tm1.1Doca |
Gene/Transgene symbol | Ago2 |
Information from provider
Provider | Donal O'Carroll |
Provider affiliation | Mouse Biology Unit, European Molecular Biology Laboratory |
Genetic information | Two point mutations in exon 10, converting Serine 388 in an Alanine residue. Residual LoxP site between exon 8 and 9 due to removal of neomycin resistance cassette. |
Phenotypic information | Mice are viable and fertile. No detectable defects of the hematopoietic system too in homeostatic conditions. |
Breeding history | The mice were backcrossed 13 times with C57BL/6N mice from Harlan. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
MGI phenotypes (gene matching)
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