- belly spot / MGI
- decreased body length / MGI
- decreased body weight / MGI
- postnatal growth retardation / MGI
- non-pigmented tail tip / MGI
- decreased tail pigmentation / MGI
- decreased foot pigmentation / MGI
- abnormal translation / MGI
- abnormal embryo development / MGI
- absent egg cylinders / MGI
- embryonic lethality between implantation and placentation, complete penetrance / MGI
C57BL/6-Rack1tm1Sbif/Cnrm
Status | Available to order |
EMMA ID | EM:07110 |
Citation information | RRID:IMSR_EM:07110 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6-Rack1tm1Sbif/Cnrm |
Alternative name | DF/RACK1 |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Rack1tm1Sbif |
Gene/Transgene symbol | Rack1 |
Information from provider
Provider | STEFANO BIFFO |
Provider affiliation | San Raffaele Scientific Institute |
Genetic information | Hypomorphic expression of the Rack1 locus (RACK1 protein) due to interference by the neomycin cassette. |
Phenotypic information | Lethal at gastrulation in homozygosis. Bellyspot phenotype in heterozygosis with reduction of translational efficiency. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- belly spot / MGI
- decreased body length / MGI
- decreased body weight / MGI
- abnormal embryo development / MGI
- absent egg cylinders / MGI
- postnatal growth retardation / MGI
- non-pigmented tail tip / MGI
- embryonic lethality between implantation and placentation, complete penetrance / MGI
- decreased tail pigmentation / MGI
- decreased foot pigmentation / MGI
- abnormal translation / MGI
Literature references
- RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency.;Volta Viviana, Beugnet Anne, Gallo Simone, Magri Laura, Brina Daniela, Pesce Elisa, Calamita Piera, Sanvito Francesca, Biffo Stefano, ;2013;Cellular and molecular life sciences : CMLS;70;1439-50; 23212600
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