- belly spot / MGI
- decreased body length / MGI
- decreased body weight / MGI
- postnatal growth retardation / MGI
- non-pigmented tail tip / MGI
- decreased tail pigmentation / MGI
- decreased foot pigmentation / MGI
- abnormal translation / MGI
- abnormal embryo development / MGI
- absent egg cylinders / MGI
- embryonic lethality between implantation and placentation, complete penetrance / MGI
C57BL/6-Rack1tm1Sbif/Cnrm
Status | Available to order |
EMMA ID | EM:07110 |
International strain name | C57BL/6-Rack1tm1Sbif/Cnrm |
Alternative name | DF/RACK1 |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Rack1tm1Sbif |
Gene/Transgene symbol | Rack1 |
Information from provider
Provider | STEFANO BIFFO |
Provider affiliation | San Raffaele Scientific Institute |
Genetic information | Hypomorphic expression of the Rack1 locus (RACK1 protein) due to interference by the neomycin cassette. |
Phenotypic information | Lethal at gastrulation in homozygosis. Bellyspot phenotype in heterozygosis with reduction of translational efficiency. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- belly spot / MGI
- decreased body length / MGI
- decreased body weight / MGI
- abnormal embryo development / MGI
- absent egg cylinders / MGI
- postnatal growth retardation / MGI
- non-pigmented tail tip / MGI
- embryonic lethality between implantation and placentation, complete penetrance / MGI
- decreased tail pigmentation / MGI
- decreased foot pigmentation / MGI
- abnormal translation / MGI
Literature references
- RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency.;Volta Viviana, Beugnet Anne, Gallo Simone, Magri Laura, Brina Daniela, Pesce Elisa, Calamita Piera, Sanvito Francesca, Biffo Stefano, ;2013;Cellular and molecular life sciences : CMLS;70;1439-50; 23212600
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