B6N.Cg-Piwil2tm2.2Doca/Cnrm
Status | Available to order |
EMMA ID | EM:07098 |
International strain name | B6N.Cg-Piwil2tm2.2Doca/Cnrm |
Alternative name | MiliNull |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Piwil2tm2.2Doca |
Gene/Transgene symbol | Piwil2 |
Information from provider
Provider | Donal O'Carroll |
Provider affiliation | Mouse Biology Unit, European Molecular Biology Laboratory |
Genetic information | Exon 21 was flanked by two loxP sites for the formation of a null allele through Cre recombination. |
Phenotypic information | Male sterility due to a meiotic arrest, transposons derepression due to DNA-methylation defect. |
Breeding history | The mouse was backcrossed 8 times with C57BL/6N mice. |
References |
|
Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
Literature references
- Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis.;Di Giacomo Monica, Comazzetto Stefano, Saini Harpreet, De Fazio Serena, Carrieri Claudia, Morgan Marcos, Vasiliauskaite Lina, Benes Vladimir, Enright Anton J, O'Carroll Dónal, ;2013;Molecular cell;50;601-8; 23706823
- G9a co-suppresses LINE1 elements in spermatogonia.;Di Giacomo Monica, Comazzetto Stefano, Sampath Srihari C, Sampath Srinath C, O'Carroll Dónal, ;2014;Epigenetics & chromatin;7;24; 25276231
- Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus.;Gasperini Caterina, Tuntevski Kiril, Beatini Silvia, Pelizzoli Roberta, Lo Van Amanda, Mangoni Damiano, Cossu Rosa M, Pascarella Giovanni, Bianchini Paolo, Bielefeld Pascal, Scarpato Margherita, Pons-Espinal Meritxell, Sanges Remo, Diaspro Alberto, Fitzsimons Carlos P, Carninci Piero, Gustincich Stefano, De Pietri Tonelli Davide, ;2023;EMBO reports;24;e53801; 36472244
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