| Status | Available to order |
| EMMA ID | EM:07073 |
| International strain name | B6.Cg-Tnfsf11tles/Flmg |
| Alternative name | B6.Tnfsf11tles (synonym: RANKLG278R) |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Tnfsf11tles |
| Gene/Transgene symbol | Tnfsf11 |
| Provider | Eleni Douni |
| Provider affiliation | Institute of Immunology, B.S.R.C. Al. Fleming |
| Additional owner | Prof. George Kollias, BSRC Alexander Fleming, Vari/Athens, Greece |
| Genetic information | ENU-mutagenesis induced a point mutation (G to A) that results in the amino acid substitution of arginine for glycine at position 278 (G278R). |
| Phenotypic information | Homozygous mice develop osteopetrosis, lack of tooth eruption (the mice are toothless, which means that 10 days after birth it appears that they have no teeth), thymus hypoplasia, splenomegaly, absence of lymph nodes and premature lethality (60% died by the 7th week of age). Heterozygous mice are healthy. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | Morula |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
