C57BL/6N-Atm1Brd B9d2tm1a(EUCOMM)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:07032
Citation informationRRID:IMSR_EM:07032 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd B9d2tm1a(EUCOMM)Wtsi/WtsiBiat
Alternative nameEPD0481_2_D09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolB9d2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolB9d2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0481_2_D09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal vertebral body morphology / MGI
  • abnormal rib morphology / MGI
  • abnormal interatrial septum morphology / MGI
  • double outlet right ventricle / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • abnormal maxilla morphology / MGI
  • polydactyly / MGI
  • abnormal liver morphology / MGI
  • abnormal adrenal gland morphology / MGI
  • small spleen / MGI
  • abnormal tongue epithelium morphology / MGI
  • abnormal forebrain morphology / MGI
  • abnormal olfactory bulb morphology / MGI
  • abnormal choroid plexus morphology / MGI
  • abnormal hindbrain morphology / MGI
  • abnormal spinal cord morphology / MGI
  • small superior cervical ganglion / MGI
  • absent oculomotor nerve / MGI
  • small superior vagus ganglion / MGI
  • abnormal ovary morphology / MGI
  • abnormal pancreas morphology / MGI
  • abnormal brain morphology / MGI
  • abnormal nasal septum morphology / MGI
  • abnormal diaphragm morphology / MGI
  • aphakia / MGI
  • left pulmonary isomerism / MGI
  • intestinal/bowel diverticulum / MGI
  • accessory spleen / MGI
  • bifid ureter / MGI
  • abnormal eye muscle morphology / MGI
  • abnormal Mullerian duct morphology / MGI
  • transposition of great arteries / MGI
  • heterotaxia / MGI
  • abnormal adenohypophysis morphology / MGI
  • abnormal neurohypophysis morphology / MGI
  • small pancreas / MGI
  • abnormal optic stalk morphology / MGI
  • abnormal optic cup morphology / MGI
  • abnormal vertebral arch morphology / MGI
  • fusion of vertebral arches / MGI
  • absent upper incisors / MGI
  • abnormal brain vasculature morphology / MGI
  • abnormal incisor morphology / MGI
  • abnormal heart position or orientation / MGI
  • abnormal brain internal capsule morphology / MGI
  • absent adenohypophysis / MGI
  • thoracoschisis / MGI
  • abnormal optic chiasm morphology / MGI
  • enlarged lymphatic vessel / MGI
  • common atrium / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • double outlet left ventricle / MGI
  • double inlet heart left ventricle / MGI
  • abnormal hepatic vein morphology / MGI
  • anomalous pulmonary venous connection / MGI
  • abnormal pectinate muscle morphology / MGI
  • aortic arch coarctation / MGI
  • bicuspid pulmonary valve / MGI
  • persistent right dorsal aorta / MGI
  • abnormal mitral valve cusp morphology / MGI
  • abdominal situs ambiguus / MGI
  • enlarged brain ventricles / MGI
  • double ureter / MGI
  • abnormal vertebral artery morphology / MGI
  • dual inferior vena cava / MGI
  • ectopic ovary / MGI
  • absent segment of anterior cerebral artery / MGI
  • thin oculomotor nerve / MGI
  • abnormal intrathoracic topology of vagus nerve / MGI
  • abnormal hypoglossal nerve topology / MGI
  • absent segment of posterior cerebral artery / MGI
  • ductus venosus stenosis / MGI
  • subcutaneous edema / MGI
  • abnormal ductus venosus topology / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve topology / MGI
  • persistent right 6th pharyngeal arch artery / MGI
  • thin motoric part of trigeminal nerve / MGI
  • abnormal thymus topology / MGI
  • abnormal infrahyoid muscle connection / MGI
  • reduced sympathetic cervical ganglion size / MGI
  • blood in lymph vessels / MGI
  • symmetric azygos veins / MGI
  • abnormal subclavian artery origin / MGI
  • inverse situs of great intrathoracic arteries / MGI
  • abnormal umbilical vein topology / MGI
  • abnormal vitelline vein topology / MGI
  • absent intrahepatic inferior vena cava segment / MGI
  • anastomosis between internal carotid artery and basilar artery / MGI
  • abnormal vertebral artery topology / MGI
  • additional anastomosis between intracranial vertebral arteries / MGI
  • abnormal Wolffian duct connection / MGI
  • embryo tumor / MGI
  • embryo cyst / MGI
  • abnormal intestine placement / MGI
  • hemangioma / MGI
  • short tongue / MGI
  • left sided inferior vena cava / MGI

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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