- decreased grip strength / IMPC
- decreased total retina thickness / IMPC
- decreased NK cell number / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- abnormal spleen morphology / IMPC
- abnormal uterus morphology / IMPC
- abnormal eye morphology / IMPC
- increased prepulse inhibition / IMPC
- small seminal vesicle / IMPC
- immune system phenotype / IMPC
- increased circulating creatinine level / IMPC
- increased fasting circulating glucose level / IMPC
- abnormal seminal vesicle morphology / IMPC
- microphthalmia / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
- enlarged spleen / IMPC
- abnormal retina inner nuclear layer morphology / IMPC
129S-Parp1tm1Zqw/Cnrm
Status | Available to order |
EMMA ID | EM:00007 |
Citation information | RRID:IMSR_EM:00007 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | 129S-Parp1tm1Zqw/Cnrm |
Alternative name | Adprt(Parp)-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Parp1tm1Zqw |
Gene/Transgene symbol | Parp1 |
Information from provider
Provider | Erwin Wagner |
Provider affiliation | IMP-Research Inst. Molecular Pathology Wien |
Genetic information | Direct gene inactivation generating a null mutation, see Wang et al., 1995, Genes & Development 9, 509-520. |
Phenotypic information | Susceptibility to skin disease. Oncogenesis, genomic stability and apoptosis models. |
References |
|
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- decreased inflammatory response / MGI
- decreased neuron apoptosis / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal microglial cell physiology / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- increased renal glomerular filtration rate / MGI
- decreased circulating creatinine level / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased renal tubule apoptosis / MGI
- immune system phenotype / MGI
- enhanced wound healing / MGI
- decreased susceptibility to injury / MGI
- decreased cell proliferation / MGI
- skin hyperplasia / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
MGI phenotypes (gene matching)
- decreased cell proliferation / MGI
- skin hyperplasia / MGI
- decreased body weight / MGI
- increased mortality induced by gamma-irradiation / MGI
- abnormal inflammatory response / MGI
- decreased inflammatory response / MGI
- decreased litter size / MGI
- abnormal macrophage physiology / MGI
- enhanced wound healing / MGI
- no phenotypic analysis / MGI
- abnormal leukocyte migration / MGI
- decreased neuron apoptosis / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal microglial cell physiology / MGI
- elevated level of mitotic sister chromatid exchange / MGI
- increased mortality induced by ionizing radiation / MGI
- induced chromosome breakage / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- abnormal cell cycle checkpoint function / MGI
- decreased susceptibility to noise-induced hearing loss / MGI
- decreased susceptibility to injury / MGI
- immune system phenotype / MGI
- increased renal glomerular filtration rate / MGI
- decreased circulating creatinine level / MGI
- increased apoptosis / MGI
- abnormal DNA repair / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased circulating interleukin-1 beta level / MGI
- decreased susceptibility to endotoxin shock / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- prenatal lethality, incomplete penetrance / MGI
- decreased renal tubule apoptosis / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
Literature references
- Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.;Wang Z Q, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner E F, ;1995;Genes & development;9;509-20; 7698643
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