C57BL/6NTac-Gfi1btm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:06985
Citation informationRRID:IMSR_EM:06985 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Gfi1btm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0515_4_E11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGfi1btm1a(EUCOMM)Hmgu
Gene/Transgene symbolGfi1b
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0515_4_E11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased neutrophil cell number / IMPC
  • increased total body fat amount / IMPC
  • increased lymphocyte cell number / IMPC
  • prenatal lethality / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased circulating bilirubin level / IMPC
  • increased circulating serum albumin level / IMPC
MGI phenotypes (gene matching)
  • absent erythrocytes / MGI
  • abnormal megakaryocyte differentiation / MGI
  • abnormal erythropoiesis / MGI
  • internal hemorrhage / MGI
  • edema / MGI
  • hemorrhage / MGI
  • pallor / MGI
  • abnormal embryonic erythropoiesis / MGI
  • abnormal embryonic erythrocyte morphology / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Genotyping protocol

Example health report
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