C57BL/6NTac-Tulp3tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:06981
Citation informationRRID:IMSR_EM:06981 

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International strain nameC57BL/6NTac-Tulp3tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0508_5_B01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTulp3tm1a(EUCOMM)Hmgu
Gene/Transgene symbolTulp3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0508_5_B01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased prepulse inhibition / IMPC
  • decreased lean body mass / IMPC
  • abnormal response to new environment / IMPC
  • increased circulating bilirubin level / IMPC
  • increased total body fat amount / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • impaired glucose tolerance / IMPC
  • decreased fasting circulating glucose level / IMPC
  • increased circulating alanine transaminase level / IMPC
MGI phenotypes (gene matching)
  • abnormal vertebrae morphology / MGI
  • rib bifurcation / MGI
  • abnormal head morphology / MGI
  • polydactyly / MGI
  • abnormal forebrain morphology / MGI
  • forebrain hypoplasia / MGI
  • abnormal hindbrain morphology / MGI
  • abnormal midbrain morphology / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • incomplete rostral neuropore closure / MGI
  • open neural tube / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • abnormal eye development / MGI
  • anemia / MGI
  • internal hemorrhage / MGI
  • edema / MGI
  • hemorrhage / MGI
  • intracranial hemorrhage / MGI
  • abnormal digit morphology / MGI
  • abnormal neural tube morphology / MGI
  • abnormal brain morphology / MGI
  • abnormal neuron specification / MGI
  • spina bifida / MGI
  • pallor / MGI
  • abnormal nervous system development / MGI
  • abnormal craniofacial development / MGI
  • abnormal vertebrae development / MGI
  • spina bifida occulta / MGI
  • increased apoptosis / MGI
  • abnormal hindbrain development / MGI
  • clinodactyly / MGI
  • facial cleft / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • embryonic lethality, incomplete penetrance / MGI
  • abnormal caudal neuropore morphology / MGI
  • spina bifida cystica / MGI
  • increased embryonic neuroepithelium apoptosis / MGI
  • decreased embryonic neuroepithelium thickness / MGI
  • incomplete caudal neuropore closure / MGI

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Genotyping protocol

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