C57BL/6N-Atm1Brd Fyntm1a(EUCOMM)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:06933
Citation informationRRID:IMSR_EM:06933 

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International strain nameC57BL/6N-Atm1Brd Fyntm1a(EUCOMM)Wtsi/WtsiBiat
Alternative nameEPD0682_4_D03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFyntm1a(EUCOMM)Wtsi
Gene/Transgene symbolFyn
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0682_4_D03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

IMPC phenotypes (allele matching)
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • decreased corpus callosum size / MGI
  • abnormal stratification in cerebral cortex / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal dentate gyrus morphology / MGI
  • abnormal hippocampus layer morphology / MGI
  • abnormal olfactory bulb morphology / MGI
  • abnormal hypothalamus morphology / MGI
  • abnormal somatosensory cortex morphology / MGI
  • abnormal myelination / MGI
  • small seminiferous tubules / MGI
  • abnormal optic nerve morphology / MGI
  • abnormal pup retrieval / MGI
  • abnormal maternal nurturing / MGI
  • abnormal suckling behavior / MGI
  • abnormal spatial learning / MGI
  • reduced long term potentiation / MGI
  • abnormal startle reflex / MGI
  • audiogenic seizures / MGI
  • abnormal immune cell physiology / MGI
  • abnormal T cell activation / MGI
  • increased dopamine level / MGI
  • abnormal olfaction / MGI
  • abnormal seminiferous tubule morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal macrophage physiology / MGI
  • abnormal eosinophil physiology / MGI
  • decreased IgE level / MGI
  • increased IgM level / MGI
  • oligozoospermia / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • abnormal cytokine secretion / MGI
  • no phenotypic analysis / MGI
  • increased fear-related response / MGI
  • abnormal thymocyte activation / MGI
  • enhanced passive avoidance behavior / MGI
  • increased susceptibility to experimental autoimmune uveoretinitis / MGI
  • decreased testis weight / MGI
  • abnormal T cell clonal deletion / MGI
  • decreased T cell number / MGI
  • abnormal T cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased susceptibility to type I hypersensitivity reaction / MGI
  • abnormal hippocampus pyramidal cell layer / MGI
  • decreased gamma-delta T cell number / MGI
  • increased IgG2a level / MGI
  • increased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • abnormal interleukin secretion / MGI
  • decreased interleukin-2 secretion / MGI
  • abnormal interleukin-4 secretion / MGI
  • increased interleukin-5 secretion / MGI
  • abnormal chemokine level / MGI
  • enhanced behavioral response to alcohol / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • increased hippocampus pyramidal cell number / MGI
  • ectopic hippocampus pyramidal cells / MGI
  • increased serotonin level / MGI
  • abnormal NK cell physiology / MGI
  • abnormal Sertoli cell barrier morphology / MGI
  • prolonged circadian behavior period / MGI
  • abnormal locomotor circadian rhythm / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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