STOCK Fgf7tm1e(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:06912
International strain nameSTOCK Fgf7tm1e(EUCOMM)Hmgu/H
Alternative nameHEPD0617_5_F12
Strain typeTargeted Mutant Strains : Targeted Non-conditional
Allele/Transgene symbolFgf7tm1e(EUCOMM)Hmgu
Gene/Transgene symbolFgf7
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0617_5_F12. For further details on the construction of this clone see the page at the IMPC portal. The targeted allele has lost the 3' loxP site. These mutations cannot be converted into conditional alleles. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • mydriasis / IMPC
  • abnormal startle reflex / IMPC
  • impaired pupillary reflex / IMPC
  • abnormal placement of pupils / IMPC
  • irregularly shaped pupil / IMPC
  • abnormal iris morphology / IMPC
  • abnormal tail length / IMPC
  • impaired righting response / IMPC
MGI phenotypes (gene matching)
  • abnormal kidney development / MGI
  • spleen hypoplasia / MGI
  • abnormal coat appearance / MGI
  • disheveled coat / MGI
  • abnormal immune system physiology / MGI
  • increased susceptibility to pharmacologically induced seizures / MGI
  • small kidney / MGI
  • matted coat / MGI
  • greasy coat / MGI
  • abnormal synaptic vesicle morphology / MGI
  • abnormal synaptic vesicle number / MGI
  • abnormal synaptic vesicle clustering / MGI
  • impaired branching involved in ureteric bud morphogenesis / MGI
  • homeostasis/metabolism phenotype / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal response to transplant / MGI
  • abnormal miniature inhibitory postsynaptic currents / MGI
  • integument phenotype / MGI
  • decreased nephron number / MGI
  • abnormal papillary duct morphology / MGI
  • abnormal kidney inner medulla morphology / MGI
  • kidney cortex hypoplasia / MGI
  • kidney papillary hypoplasia / MGI
  • abnormal kidney collecting duct epithelium morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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