NOD.129S2-Parp1tm1Zqw/Ieg

Status

Available to order

EMMA IDEM:06909
Citation informationRRID:IMSR_EM:06909 

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International strain nameNOD.129S2-Parp1tm1Zqw/Ieg
Alternative nameNOD-Parp1tm1Zqw
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolParp1tm1Zqw
Gene/Transgene symbolParp1

Information from provider

ProviderVolker Burkart
Provider affiliationInstitute for Clinical Diabetology, German Diabetes Center
Additional ownerDr. Z.Q. Wang, Leibniz Institute for Age Research - Fritz Lipmann Institute, Jena, Germany
Genetic informationA promoterless neomycin gene replaced part of exon 2 and intron 2. The neomycin sequences were fused in-frame to the coding sequence of the gene. Northern blot analysis detected a truncated fusion transcript in homozygous mice. Enzyme activity assays demonstrated a lack of functional ADPRT1 protein in homozygous mice.
Phenotypic informationAbnormal sensitivity of pancreatic islet cells to beta cell damaging mediators.
Breeding historyMore than 10 backcross generations to female NOD. Every 2nd generation intercrossed, currently inbred.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased grip strength / IMPC
  • decreased total retina thickness / IMPC
  • decreased NK cell number / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal spleen morphology / IMPC
  • abnormal uterus morphology / IMPC
  • abnormal eye morphology / IMPC
  • increased prepulse inhibition / IMPC
  • small seminal vesicle / IMPC
  • immune system phenotype / IMPC
  • increased circulating creatinine level / IMPC
  • increased fasting circulating glucose level / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • microphthalmia / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • enlarged spleen / IMPC
  • abnormal retina inner nuclear layer morphology / IMPC
MGI phenotypes (allele matching)
  • decreased inflammatory response / MGI
  • decreased neuron apoptosis / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal microglial cell physiology / MGI
  • decreased susceptibility to kidney reperfusion injury / MGI
  • increased renal glomerular filtration rate / MGI
  • decreased circulating creatinine level / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased renal tubule apoptosis / MGI
  • immune system phenotype / MGI
  • enhanced wound healing / MGI
  • decreased susceptibility to injury / MGI
  • decreased cell proliferation / MGI
  • skin hyperplasia / MGI
  • decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
MGI phenotypes (gene matching)
  • decreased cell proliferation / MGI
  • skin hyperplasia / MGI
  • decreased body weight / MGI
  • increased mortality induced by gamma-irradiation / MGI
  • abnormal inflammatory response / MGI
  • decreased inflammatory response / MGI
  • decreased litter size / MGI
  • abnormal macrophage physiology / MGI
  • enhanced wound healing / MGI
  • no phenotypic analysis / MGI
  • abnormal leukocyte migration / MGI
  • decreased neuron apoptosis / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal microglial cell physiology / MGI
  • elevated level of mitotic sister chromatid exchange / MGI
  • increased mortality induced by ionizing radiation / MGI
  • induced chromosome breakage / MGI
  • decreased susceptibility to kidney reperfusion injury / MGI
  • abnormal cell cycle checkpoint function / MGI
  • decreased susceptibility to noise-induced hearing loss / MGI
  • decreased susceptibility to injury / MGI
  • immune system phenotype / MGI
  • increased renal glomerular filtration rate / MGI
  • decreased circulating creatinine level / MGI
  • increased apoptosis / MGI
  • abnormal DNA repair / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased circulating interleukin-1 beta level / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • decreased renal tubule apoptosis / MGI
  • decreased susceptibility to dopaminergic neuron neurotoxicity / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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