| Status | Available to order |
| EMMA ID | EM:06876 |
| Citation information | RRID:IMSR_EM:06876 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Nrxn2tm1Sud/H |
| Alternative name | Nrxn2tm1Sud |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nrxn2tm1Sud |
| Gene/Transgene symbol | Nrxn2 |
| Provider | Markus Missler |
| Provider affiliation | Department of Anatomy and Molecular Neurobiology, Westfälische Wilhelms-University Münster |
| Genetic information | A neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS (Laminin alpha, Neurexins, and Sex hormone-binding globulin) domain. Immunoblotting of mutant brain confirmed lack of protein. |
| Phenotypic information | Mice homozygous for a knock-out allele show a 30-40% decrease in body weight and their inhibitory postsynaptic currents (IPSCs) are decreased in cortical slice cultures. |
| Breeding history | Backcrossed for 8 generations to C57BL/6J. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
MGI allele-associated human disease models
