C57BL/6N-Epas1tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:06875
International strain nameC57BL/6N-Epas1tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0726_2_B11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolEpas1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolEpas1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0726_2_B11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • decreased hemoglobin content / IMPC
  • increased total body fat amount / IMPC
  • abnormal heart morphology / IMPC
MGI phenotypes (gene matching)
  • increased leukocyte cell number / MGI
  • increased monocyte cell number / MGI
  • abnormal angiogenesis / MGI
  • abnormal lung development / MGI
  • atelectasis / MGI
  • thick pulmonary interalveolar septum / MGI
  • abnormal cardiovascular system physiology / MGI
  • cyanosis / MGI
  • hemorrhage / MGI
  • respiratory failure / MGI
  • respiratory distress / MGI
  • abnormal pulmonary alveolus epithelial cell morphology / MGI
  • increased hematocrit / MGI
  • increased heart weight / MGI
  • thick ventricular wall / MGI
  • increased erythrocyte cell number / MGI
  • abnormal vitelline vasculature morphology / MGI
  • abnormal physiological neovascularization / MGI
  • abnormal retinal inner nuclear layer morphology / MGI
  • abnormal lung vasculature morphology / MGI
  • abnormal surfactant secretion / MGI
  • increased spleen weight / MGI
  • increased lymphocyte cell number / MGI
  • decreased susceptibility to injury / MGI
  • decreased heart rate / MGI
  • abnormal eye electrophysiology / MGI
  • increased hemoglobin content / MGI
  • increased pulmonary respiratory rate / MGI
  • decreased circulating noradrenaline level / MGI
  • congestive heart failure / MGI
  • decreased birth body size / MGI
  • visceral vascular congestion / MGI
  • liver vascular congestion / MGI
  • heart vascular congestion / MGI
  • pulmonary artery hypoplasia / MGI
  • abnormal heart right ventricle pressure / MGI
  • decreased type II pneumocyte number / MGI
  • abnormal alveolar lamellar body morphology / MGI
  • lethality, incomplete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • increased circulating erythropoietin level / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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