C57BL/6N-Atm1Brd Nadk2tm1a(EUCOMM)Wtsi/WtsiCnrm

Status

Available to order

EMMA IDEM:06861
International strain nameC57BL/6N-Atm1Brd Nadk2tm1a(EUCOMM)Wtsi/WtsiCnrm
Alternative nameEPD0638_1_A06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNadk2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolNadk2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0638_1_A06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Progressive encephalopathy with leukodystrophy due to DECR deficiency / Orphanet_431361
IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • decreased fasting circulating glucose level / IMPC
  • persistence of hyaloid vascular system / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • abnormal embryo turning / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
MGI phenotypes (gene matching)
  • enlarged liver / MGI
  • pale liver / MGI
  • abnormal liver physiology / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating free fatty acid level / MGI
  • hepatic steatosis / MGI
  • liver degeneration / MGI
  • liver fibrosis / MGI
  • oxidative stress / MGI
  • increased circulating carnitine level / MGI
  • decreased energy expenditure / MGI
  • increased liver triglyceride level / MGI
  • increased respiratory quotient / MGI
  • decreased fatty acid oxidation / MGI
  • increased circulating lysine level / MGI
  • increased lysine level / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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