C57BL/6NTac-Syt1tm1a(EUCOMM)Wtsi/WtsiCnrm

Status

Available to order

EMMA IDEM:06829
International strain nameC57BL/6NTac-Syt1tm1a(EUCOMM)Wtsi/WtsiCnrm
Alternative nameEPD0214_1_H11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSyt1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSyt1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0214_1_H11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome / Orphanet_522077
IMPC phenotypes (allele matching)
  • decreased lean body mass / IMPC
  • decreased bone mineral content / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • decreased lean body mass / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased bone mineral content / IMPC
MGI phenotypes (allele matching)
  • dilated bile duct / MGI
  • biliary cyst / MGI
  • thoracoschisis / MGI
  • perimembraneous ventricular septal defect / MGI
  • adrenal gland cyst / MGI
  • thyroid cyst / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal infrahyoid muscle connection / MGI
  • abnormal coronary sinus connection / MGI
MGI phenotypes (gene matching)
  • abnormal suckling behavior / MGI
  • no abnormal phenotype detected / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal adrenal gland physiology / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • increased synaptic depression / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • dilated bile duct / MGI
  • biliary cyst / MGI
  • nervous system phenotype / MGI
  • abnormal synaptic transmission / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • abnormal neuron physiology / MGI
  • abnormal neurotransmitter secretion / MGI
  • thoracoschisis / MGI
  • perimembraneous ventricular septal defect / MGI
  • postnatal lethality, complete penetrance / MGI
  • adrenal gland cyst / MGI
  • thyroid cyst / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal infrahyoid muscle connection / MGI
  • abnormal coronary sinus connection / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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