C3.C-Pde6b+/Ieg

Status

Available to order

EMMA IDEM:06821
International strain nameC3.C-Pde6b+/Ieg
Alternative nameC3H sighted
Strain typeOther
Allele/Transgene symbolPde6b+
Gene/Transgene symbolPde6b

Information from provider

ProviderOliver Puk
Provider affiliationInstitut fuer Entwicklungsgenetik, AG Graw, Helmholtz Zentrum Muenchen
Genetic informationPde6b rd1 is removed by an intact Pde6b allele.

Disclaimer - Special restrictions:

1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols.
2) Some lines showed low penetrance of the phenotype.
3) Only sperm available. Rederivation service can not be offered.
4) EMMA quality control standards may not apply for these strains.
5) EMMA has not verified the breeding performance and the genetic background of the strains.

The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt.
Phenotypic informationC3H sighted strain carries a functional Pde6b allele that avoids retinal degeneration.
Breeding historyIncross, 10 generations
References
  • "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?;Hoelter Sabine M, Dalke Claudia, Kallnik Magdalena, Becker Lore, Horsch Marion, Schrewe Anja, Favor Jack, Klopstock Thomas, Beckers Johannes, Ivandic Boris, Gailus-Durner Valérie, Fuchs Helmut, Hrabé de Angelis Martin, Graw Jochen, Wurst Wolfgang, ;2008;Frontiers in bioscience : a journal and virtual library;13;5810-23; 18508624
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal whole-body plethysmography / IMPC
  • decreased circulating amylase level / IMPC
  • atrophy / IMPC
  • decreased defecation amount / IMPC
  • decreased body weight / IMPC
  • abnormal heart morphology / IMPC
  • increased cellular hemoglobin content / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased body temperature / IMPC
  • increased circulating potassium level / IMPC
  • increased mean corpuscular volume / IMPC
  • decreased locomotor activity / IMPC
  • increased blood uric acid level / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
  • enlarged heart / IMPC
MGI phenotypes (gene matching)
  • abnormal retinal rod cell morphology / MGI
  • abnormal retina morphology / MGI
  • retinal degeneration / MGI
  • decreased retinal photoreceptor cell number / MGI
  • blindness / MGI
  • abnormal retinal vasculature morphology / MGI
  • abnormal ocular fundus morphology / MGI
  • abnormal photoreceptor outer segment morphology / MGI
  • abnormal retinal outer nuclear layer morphology / MGI
  • abnormal rod electrophysiology / MGI
  • abnormal cone electrophysiology / MGI
  • vision/eye phenotype / MGI
  • abnormal Muller cell morphology / MGI
  • abnormal eye electrophysiology / MGI
  • decreased visual acuity / MGI
  • impaired pupillary reflex / MGI
  • abnormal optic disk morphology / MGI
  • retinal photoreceptor degeneration / MGI
  • retinal rod cell degeneration / MGI
  • absent retinal rod cells / MGI
  • thin retinal outer nuclear layer / MGI
  • retinal outer nuclear layer degeneration / MGI
  • absent photoreceptor outer segment / MGI
  • abnormal retinal blood vessel morphology / MGI
  • decreased total retina thickness / MGI

Literature references

  • "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?;Hoelter Sabine M, Dalke Claudia, Kallnik Magdalena, Becker Lore, Horsch Marion, Schrewe Anja, Favor Jack, Klopstock Thomas, Beckers Johannes, Ivandic Boris, Gailus-Durner Valérie, Fuchs Helmut, Hrabé de Angelis Martin, Graw Jochen, Wurst Wolfgang, ;2008;Frontiers in bioscience : a journal and virtual library;13;5810-23; 18508624

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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