B6.Cg-Tg(Slc16a1-Luc)50Rttr/H
| Status | Available to order |
| EMMA ID | EM:06818 |
| Citation information | RRID:IMSR_EM:06818 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Slc16a1-Luc)50Rttr/H |
| Alternative name | Mct1-Luc |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Slc16a1-luc)50Rttr |
| Gene/Transgene symbol | Tg(Slc16a1-luc)50Rttr |
Information from provider
| Provider | Guy Rutter |
| Provider affiliation | Section of Cell Biology, Department of Medicine, Imperial College London |
| Genetic information | Transgenic mouse capable of tetracycline-inducible expression of Mct1 (Slc16a1) and firefly luciferase, when crossed with a tTA or rtTA expressing strain. |
| Phenotypic information | When expressed in pancreatic beta cells it renders insulin secretion sensitive to pyruvate and prevents the normal inhibition of insulin secretion induced by exercise, replicating the key features of Exercise-Induced Hyperinsulinism. |
| Breeding history | Founders have been backcrossed 7 times to C57BL/6 mice. Currently maintained either as heterozygotes crossed with C57BL/6 or as homozygotes crossed with each other. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.;Pullen Timothy J, Sylow Lykke, Sun Gao, Halestrap Andrew P, Richter Erik A, Rutter Guy A, ;2012;Diabetes;61;1719-25; 22522610