B6.Cg-Tg(Slc16a1-Luc)50Rttr/H
| Status | Available to order |
| EMMA ID | EM:06818 |
| International strain name | B6.Cg-Tg(Slc16a1-Luc)50Rttr/H |
| Alternative name | Mct1-Luc |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Slc16a1-luc)50Rttr |
| Gene/Transgene symbol | Tg(Slc16a1-luc)50Rttr |
Information from provider
| Provider | Guy Rutter |
| Provider affiliation | Section of Cell Biology, Department of Medicine, Imperial College London |
| Genetic information | Transgenic mouse capable of tetracycline-inducible expression of Mct1 (Slc16a1) and firefly luciferase, when crossed with a tTA or rtTA expressing strain. |
| Phenotypic information | When expressed in pancreatic beta cells it renders insulin secretion sensitive to pyruvate and prevents the normal inhibition of insulin secretion induced by exercise, replicating the key features of Exercise-Induced Hyperinsulinism. |
| Breeding history | Founders have been backcrossed 7 times to C57BL/6 mice. Currently maintained either as heterozygotes crossed with C57BL/6 or as homozygotes crossed with each other. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.;Pullen Timothy J, Sylow Lykke, Sun Gao, Halestrap Andrew P, Richter Erik A, Rutter Guy A, ;2012;Diabetes;61;1719-25; 22522610