- no phenotypic analysis / MGI
B6.129P2-Gja1tm9.1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:06788 |
International strain name | B6.129P2-Gja1tm9.1Kwi/Cnrm |
Alternative name | Cx43floxCx43kiECFP |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Gja1tm9.1Kwi |
Gene/Transgene symbol | Gja1 |
Information from provider
Provider | Klaus Willecke |
Provider affiliation | Molecular genetics, LIMES Institute, University of Bonn |
Genetic information | The Cx43 (Gja1) coding region is flanked by loxP sites. After cre recombinase-mediated deletion the ECFP protein is expressed under control of the endogenous Cx43 promoter. |
Phenotypic information | Hetero- and homozygous fertile. After cre recombinase-mediated deletion homozygous lethal at P0 due to a heart failure. |
Breeding history | Targeted HM-1 cells were injected in C57BL/6NCrl blastocysts, chimeras were backcrossed to C57BL/6NCrl and offspring over more than 10 generations to C57BL/6JCrl. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant palmoplantar keratoderma and congenital alopecia / Orphanet_1010
- Oculodentodigital dysplasia / Orphanet_2710
- Craniometaphyseal dysplasia / Orphanet_1522
- Syndactyly type 3 / Orphanet_93404
- Erythrokeratodermia variabilis / Orphanet_317
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- delayed bone ossification / MGI
- decreased bone mineral density / MGI
- abnormal neurocranium morphology / MGI
- abnormal parietal bone morphology / MGI
- abnormal tooth development / MGI
- brittle teeth / MGI
- abnormal rib morphology / MGI
- abnormal heart morphology / MGI
- abnormal heart development / MGI
- abnormal heart shape / MGI
- thin ventricular wall / MGI
- abnormal interventricular septum morphology / MGI
- decreased bone marrow cell number / MGI
- abnormal cranium morphology / MGI
- pointed snout / MGI
- syndactyly / MGI
- abnormal ovary morphology / MGI
- small ovary / MGI
- impaired ovarian folliculogenesis / MGI
- abnormal ovarian follicle morphology / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- small testis / MGI
- abnormal spermatogenesis / MGI
- abnormal skin condition / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- cataract / MGI
- corneal opacity / MGI
- irregularly shaped pupil / MGI
- abnormal iris morphology / MGI
- abnormal suckling behavior / MGI
- abnormal cardiovascular system physiology / MGI
- cyanosis / MGI
- cardiac hypertrophy / MGI
- abnormal heart rate / MGI
- irregular heartbeat / MGI
- postnatal growth retardation / MGI
- edema / MGI
- heart inflammation / MGI
- abnormal lactation / MGI
- reduced female fertility / MGI
- male infertility / MGI
- female infertility / MGI
- decreased litter size / MGI
- abnormal breathing pattern / MGI
- ovary cysts / MGI
- perinatal lethality / MGI
- premature death / MGI
- abnormal tooth morphology / MGI
- abnormal digit morphology / MGI
- abnormal craniofacial bone morphology / MGI
- no abnormal phenotype detected / MGI
- small heart / MGI
- decreased germ cell number / MGI
- abnormal seminiferous tubule morphology / MGI
- abnormal pulmonary gas exchange / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal proerythroblast morphology / MGI
- abnormal neutrophil physiology / MGI
- reduced enamel thickness / MGI
- decreased mature ovarian follicle number / MGI
- oligozoospermia / MGI
- abnormal semilunar valve morphology / MGI
- abnormal pulmonary valve morphology / MGI
- dilated heart left ventricle / MGI
- impaired skin barrier function / MGI
- abnormal cardiac muscle contractility / MGI
- no phenotypic analysis / MGI
- short zygomatic bone / MGI
- abnormal impulse conducting system conduction / MGI
- cardiac fibrosis / MGI
- prolonged QT interval / MGI
- abnormal alisphenoid bone morphology / MGI
- decreased ovulation rate / MGI
- impaired luteinization / MGI
- delayed endochondral bone ossification / MGI
- delayed intramembranous bone ossification / MGI
- maternal effect / MGI
- abnormal milk ejection / MGI
- abnormal nervous system development / MGI
- prolonged PR interval / MGI
- shortened QT interval / MGI
- abnormal heart right ventricle morphology / MGI
- thin myocardium compact layer / MGI
- abnormal trabecula carnea morphology / MGI
- prolonged P wave / MGI
- abnormal coronary artery morphology / MGI
- abnormal atrioventricular bundle conduction / MGI
- abnormal myocardial fiber physiology / MGI
- patent cardiac foramen ovale / MGI
- small frontal bone / MGI
- interparietal bone hypoplasia / MGI
- abnormal zygomatic arch morphology / MGI
- small nasal bone / MGI
- small maxilla / MGI
- small mandible / MGI
- abnormal thoracic cage morphology / MGI
- decreased testis weight / MGI
- abnormal vascular wound healing / MGI
- decreased male germ cell number / MGI
- decreased bone strength / MGI
- abnormal osteoblast physiology / MGI
- decreased cardiac muscle contractility / MGI
- azoospermia / MGI
- abnormal occipital bone morphology / MGI
- abnormal heart ventricle morphology / MGI
- abnormal phalanx morphology / MGI
- abnormal myocardium layer morphology / MGI
- decreased heart rate / MGI
- small cranium / MGI
- abnormal incisor morphology / MGI
- hearing/vestibular/ear phenotype / MGI
- embryo phenotype / MGI
- cardiovascular system phenotype / MGI
- behavior/neurological phenotype / MGI
- vision/eye phenotype / MGI
- abnormal vascular smooth muscle physiology / MGI
- decreased ventricle muscle contractility / MGI
- decreased tympanic ring size / MGI
- semilunar valve regurgitation / MGI
- abnormal cardiac outflow tract development / MGI
- abnormal mammary gland growth during pregnancy / MGI
- abnormal spermatocyte morphology / MGI
- abnormal osteoblast differentiation / MGI
- abnormal granulosa cell morphology / MGI
- ventricular tachycardia / MGI
- abnormal mammary gland alveolus morphology / MGI
- abnormal superovulation / MGI
- ventricular premature beat / MGI
- decreased bone mineral content / MGI
- prolonged QRS complex duration / MGI
- decreased QRS amplitude / MGI
- abnormal heart right ventricle outflow tract morphology / MGI
- heart right ventricle outflow tract stenosis / MGI
- abnormal coronary vein morphology / MGI
- coronary fistula / MGI
- coronary artery aneurysm / MGI
- abnormal heart electrocardiography waveform feature / MGI
- abnormal coronary vessel morphology / MGI
- thick aortic valve / MGI
- thick pulmonary valve / MGI
- integument phenotype / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal mammary gland luminal epithelium morphology / MGI
- small lower incisors / MGI
- small snout / MGI
- thin parietal bone / MGI
- small neurocranium / MGI
Literature references
- Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity.;Degen Joachim, Dublin Pavel, Zhang Jiong, Dobrowolski Radoslaw, Jokwitz Melanie, Karram Khalad, Trotter Jacqueline, Jabs Ronald, Willecke Klaus, Steinhäuser Christian, Theis Martin, ;2012;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;26;4576-83; 22859373
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