IMPC phenotypes (gene matching)
BALB/c-Ceacam16tm1Wzm/Ieg
| Status | Available to order |
| EMMA ID | EM:06746 |
| International strain name | BALB/c-Ceacam16tm1Wzm/Ieg |
| Alternative name | Ceacam16tm1Wzm |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ceacam16tm1Wzm |
| Gene/Transgene symbol | Ceacam16 |
Information from provider
| Provider | Wolfgang Zimmermann |
| Provider affiliation | Tumor Immunology Laboratory, LIFE Center, University Hospital, Ludwig-Maximilians University Muenchen |
| Additional owner | |
| Genetic information | Ceacam16tm1Wzm mice lack a 6.8-kb region in the Ceacam16 gene that comprises exons 2-4 and part of exon 5 that was replaced by a 1.7-kb neo cassette. |
| Phenotypic information | In Ceacam16tm1Wzm mice the hearing threshold for frequencies below 10 kHz and above 22 kHz is raised. |
| Breeding history | An ES cell clone was injected into C57BL/6J blastocysts, and these were implanted into a NMRI foster mother. The resulting male chimeras were backcrossed to BALB/c females to identify germ line transmission of the targeted allele and to produce mice heterozygous for the null mutation. F1 intercrosses of heterozygous mice resulted in F2 offspring on pure BALB/c (Charles River) background. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous BALB/c, wild-type BALB/c |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
MGI phenotypes (gene matching)
Literature references
- Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.;Kammerer Robert, Rüttiger Lukas, Riesenberg Rainer, Schäuble Constanze, Krupar Rosemarie, Kamp Annegret, Sunami Kishiko, Eisenried Andreas, Hennenberg Martin, Grunert Fritz, Bress Andreas, Battaglia Sebastiano, Schrewe Heinrich, Knipper Marlies, Schneider Marlon R, Zimmermann Wolfgang, ;2012;The Journal of biological chemistry;287;21584-98; 22544735