- small kidney / MGI
- absent incus / MGI
- neonatal lethality, complete penetrance / MGI
- abnormal malleus morphology / MGI
- increased cochlear inner hair cell number / MGI
- increased cochlear outer hair cell number / MGI
- abnormal stapes morphology / MGI
- abnormal incudomalleolar joint morphology / MGI
- absent kidney / MGI
- decreased corpus callosum size / MGI
- abnormal cerebral cortex morphology / MGI
- absent dentate gyrus / MGI
- abnormal Ammon gyrus morphology / MGI
- abnormal lateral ventricle morphology / MGI
- dilated third ventricle / MGI
- small olfactory bulb / MGI
- abnormal hippocampal fimbria morphology / MGI
- abnormal hippocampal fornix morphology / MGI
- decreased anterior commissure size / MGI
- abnormal cerebral hemisphere morphology / MGI
B6.129-Emx2tm1Pgr/Cnrm
Status | Available to order |
EMMA ID | EM:00065 |
International strain name | B6.129-Emx2tm1Pgr/Cnrm |
Alternative name | Emx2-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Emx2tm1Pgr |
Gene/Transgene symbol | Emx2 |
Information from provider
Provider | Peter Gruss |
Provider affiliation | Max Planck Inst. Biophysical Chemistry |
Phenotypic information | Homozygous embryos die postnatally because of severe urogenital alterations. Emx2 is required for the development of several forebrain structures. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal malleus morphology / MGI
- abnormal cochlea morphology / MGI
- absent kidney / MGI
- abnormal kidney development / MGI
- decreased corpus callosum size / MGI
- abnormal cerebral cortex morphology / MGI
- absent dentate gyrus / MGI
- abnormal Ammon gyrus morphology / MGI
- abnormal lateral ventricle morphology / MGI
- dilated third ventricle / MGI
- deafness / MGI
- abnormal primary sex determination / MGI
- small olfactory bulb / MGI
- small kidney / MGI
- abnormal hippocampal fimbria morphology / MGI
- absent vas deferens / MGI
- absent uterus / MGI
- absent oviduct / MGI
- absent ovary / MGI
- absent seminal vesicle / MGI
- absent ureter / MGI
- abnormal pallium development / MGI
- absent incus / MGI
- abnormal cochlear inner hair cell morphology / MGI
- increased cochlear inner hair cell number / MGI
- increased cochlear outer hair cell number / MGI
- decreased cochlear nerve compound action potential / MGI
- absent epididymis / MGI
- absent efferent ductules of testis / MGI
- conductive hearing loss / MGI
- sensorineural hearing loss / MGI
- syndromic hearing loss / MGI
- increased cochlear nerve compound action potential / MGI
- impaired branching involved in ureteric bud morphogenesis / MGI
- abnormal middle ear ossicle morphology / MGI
- abnormal incus morphology / MGI
- abnormal stapes morphology / MGI
- cardiovascular system phenotype / MGI
- agonadal / MGI
- impaired hearing / MGI
- absent pinna reflex / MGI
- absent testes / MGI
- absent Mullerian ducts / MGI
- decreased anterior commissure size / MGI
- abnormal cerebral hemisphere morphology / MGI
- absent cranial vagina / MGI
- Wolffian duct degeneration / MGI
- absent internal male genitalia / MGI
- absent internal female genitalia / MGI
- abnormal metanephric mesenchyme morphology / MGI
- neonatal lethality, complete penetrance / MGI
- increased metanephric mesenchyme apoptosis / MGI
- gonadal ridge hypoplasia / MGI
- abnormal metanephric ureteric bud development / MGI
- abnormal ureteric bud tip morphology / MGI
- decreased hippocampal fornix size / MGI
- abnormal incudostapedial joint morphology / MGI
- abnormal incudomalleolar joint morphology / MGI
- abnormal incus long process morphology / MGI
- absent incus lenticular process / MGI
- abnormal stapes head morphology / MGI
Literature references
- Dentate gyrus formation requires Emx2.;Pellegrini M, Mansouri A, Simeone A, Boncinelli E, Gruss P, ;1996;Development (Cambridge, England);122;3893-8; 9012509
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