B6.129-Emx2tm1Pgr/Cnrm

Status

Under development - register interest

EMMA IDEM:00065
Citation informationRRID:IMSR_EM:00065 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129-Emx2tm1Pgr/Cnrm
Alternative nameEmx2-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolEmx2tm1Pgr
Gene/Transgene symbolEmx2

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Phenotypic informationHomozygous embryos die postnatally because of severe urogenital alterations. Emx2 is required for the development of several forebrain structures.
References
  • Dentate gyrus formation requires Emx2.;Pellegrini M, Mansouri A, Simeone A, Boncinelli E, Gruss P, ;1996;Development (Cambridge, England);122;3893-8; 9012509

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • small kidney / MGI
  • absent incus / MGI
  • neonatal lethality, complete penetrance / MGI
  • abnormal malleus morphology / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • abnormal stapes morphology / MGI
  • abnormal incudomalleolar joint morphology / MGI
  • absent kidney / MGI
  • decreased corpus callosum size / MGI
  • abnormal cerebral cortex morphology / MGI
  • absent dentate gyrus / MGI
  • abnormal Ammon gyrus morphology / MGI
  • abnormal lateral ventricle morphology / MGI
  • dilated third ventricle / MGI
  • small olfactory bulb / MGI
  • abnormal hippocampal fimbria morphology / MGI
  • abnormal hippocampal fornix morphology / MGI
  • decreased anterior commissure size / MGI
  • abnormal cerebral hemisphere morphology / MGI
MGI phenotypes (gene matching)
  • abnormal malleus morphology / MGI
  • abnormal cochlea morphology / MGI
  • absent kidney / MGI
  • abnormal kidney development / MGI
  • decreased corpus callosum size / MGI
  • abnormal cerebral cortex morphology / MGI
  • absent dentate gyrus / MGI
  • abnormal Ammon gyrus morphology / MGI
  • abnormal lateral ventricle morphology / MGI
  • dilated third ventricle / MGI
  • deafness / MGI
  • abnormal primary sex determination / MGI
  • small olfactory bulb / MGI
  • small kidney / MGI
  • abnormal hippocampal fimbria morphology / MGI
  • absent vas deferens / MGI
  • absent uterus / MGI
  • absent oviduct / MGI
  • absent ovary / MGI
  • absent seminal vesicle / MGI
  • absent ureter / MGI
  • abnormal pallium development / MGI
  • absent incus / MGI
  • abnormal cochlear inner hair cell morphology / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • decreased cochlear nerve compound action potential / MGI
  • absent epididymis / MGI
  • absent efferent ductules of testis / MGI
  • conductive hearing loss / MGI
  • sensorineural hearing loss / MGI
  • syndromic hearing loss / MGI
  • increased cochlear nerve compound action potential / MGI
  • impaired branching involved in ureteric bud morphogenesis / MGI
  • abnormal middle ear ossicle morphology / MGI
  • abnormal incus morphology / MGI
  • abnormal stapes morphology / MGI
  • cardiovascular system phenotype / MGI
  • agonadal / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • absent testes / MGI
  • absent Mullerian ducts / MGI
  • decreased anterior commissure size / MGI
  • abnormal cerebral hemisphere morphology / MGI
  • absent cranial vagina / MGI
  • Wolffian duct degeneration / MGI
  • absent internal male genitalia / MGI
  • absent internal female genitalia / MGI
  • abnormal metanephric mesenchyme morphology / MGI
  • neonatal lethality, complete penetrance / MGI
  • increased metanephric mesenchyme apoptosis / MGI
  • gonadal ridge hypoplasia / MGI
  • abnormal metanephric ureteric bud development / MGI
  • abnormal ureteric bud tip morphology / MGI
  • decreased hippocampal fornix size / MGI
  • abnormal incudostapedial joint morphology / MGI
  • abnormal incudomalleolar joint morphology / MGI
  • abnormal incus long process morphology / MGI
  • absent incus lenticular process / MGI
  • abnormal stapes head morphology / MGI

Literature references

  • Dentate gyrus formation requires Emx2.;Pellegrini M, Mansouri A, Simeone A, Boncinelli E, Gruss P, ;1996;Development (Cambridge, England);122;3893-8; 9012509

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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