B6.129P2-Bcl10tm1Mak/Cnbc

Status

Available to order

EMMA IDEM:06383
Citation informationRRID:IMSR_EM:06383 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129P2-Bcl10tm1Mak/Cnbc
Alternative nameBcl10
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolBcl10tm1Mak
Gene/Transgene symbolBcl10

Information from provider

ProviderTak W Mak
Provider affiliationMak Lab, Campbell Family Breast Cancer reseach Institute
Genetic informationA targeting vector was designed to replace exon 2 and the complete coding sequence of exon 3 with a neomycin resistance gene cassette (neo) in antisense orientation.
Phenotypic informationHeterozygous (+/-) mice were healthy up to nine months of age and intercrossed to obtain homozygous Bcl10 deficient mutants (-/-). Of 372 offspring from heterozygous intercrosses, only 65 (17.5%) homozygous mutants were identified, indicating that about one third of Bcl10-/- mutants died during embryogenesis. Bcl10-/- mutants that survived embryonic development were fertile, did not show any gross anatomical abnormalities, and did not develop any malignancies up to 6 months of age. Bcl10 deficiency results in partial embryonic lethality caused by a neural tube closure defect.
Breeding historyBackcrossed 10 times to C57BL/6.
References
  • Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.;Ruland J, Duncan G S, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar D G, Bouchard D, Wakeham A, Ohashi P S, Mak T W, ;2001;Cell;104;33-42; 11163238
  • Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection.;Jost Philipp J, Weiss Stephanie, Ferch Uta, Gross Olaf, Mak Tak W, Peschel Christian, Ruland Jürgen, ;2007;Journal of immunology (Baltimore, Md. : 1950);178;953-60; 17202357
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous C57BL/6J males

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased thymocyte number / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • abnormal immune cell physiology / MGI
  • abnormal T cell activation / MGI
  • decreased activated T cell number / MGI
  • abnormal T cell differentiation / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to infection / MGI
  • decreased immunoglobulin level / MGI
  • abnormal neural fold elevation formation / MGI
  • abnormal response to infection / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • cellular phenotype / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • increased hindbrain apoptosis / MGI
MGI phenotypes (gene matching)
  • decreased thymocyte number / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • abnormal immune cell physiology / MGI
  • abnormal T cell activation / MGI
  • decreased activated T cell number / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to infection / MGI
  • increased susceptibility to bacterial infection / MGI
  • decreased immunoglobulin level / MGI
  • increased IgM level / MGI
  • increased IgE level / MGI
  • abnormal cytokine secretion / MGI
  • abnormal neural fold elevation formation / MGI
  • decreased B-1 B cell number / MGI
  • increased T cell number / MGI
  • decreased B cell number / MGI
  • abnormal response to infection / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • cellular phenotype / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • increased single-positive T cell number / MGI
  • decreased follicular B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • abnormal marginal zone B cell physiology / MGI
  • decreased mature B cell number / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • increased hindbrain apoptosis / MGI

Literature references

  • Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.;Ruland J, Duncan G S, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar D G, Bouchard D, Wakeham A, Ohashi P S, Mak T W, ;2001;Cell;104;33-42; 11163238
  • Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection.;Jost Philipp J, Weiss Stephanie, Ferch Uta, Gross Olaf, Mak Tak W, Peschel Christian, Ruland Jürgen, ;2007;Journal of immunology (Baltimore, Md. : 1950);178;953-60; 17202357

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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