IMPC phenotypes (gene matching)
B6.129-Il2rbtm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:06371 |
| Citation information | RRID:IMSR_EM:06371 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Il2rbtm1Mak/Cnbc |
| Alternative name | IL - 2 Rb |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Il2rbtm1Mak |
| Gene/Transgene symbol | Il2rb |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Mak Lab, Campbell Family Breast Cancer reseach Institute |
| Genetic information | Mice defective in IL-2Rb expression were generated by insertion of neomycin resistance cassette into Il2rb gene at exon 6 which encodes a region of the extracellular domain proximal to the transmembrane region. |
| Phenotypic information | Homozygous mice are smaller, have abnormal hair, slow movement and poorly developed external genitals. Death occurs at 12 weeks of age. T cells are spontaneously activated causing exhaustive differentiation of B cells into plasma cells and high serum concentrations of IgG1 and IgE, as well as autoantibodies that cause hemolytic anemia. |
| Breeding history | 10 backcrosses to C57BL/6. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- abnormal T cell activation / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal lymphocyte morphology / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased susceptibility to autoimmune hemolytic anemia / MGI
- decreased regulatory T cell number / MGI
- decreased T cell proliferation / MGI
- abnormal response to transplant / MGI
- liver inflammation / MGI
- premature death / MGI
- abnormal immune system organ morphology / MGI
- abnormal T cell clonal deletion / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal marginal zone B cell morphology / MGI
- increased neutrophil cell number / MGI
- increased granulocyte number / MGI
- abnormal sex gland morphology / MGI
- weight loss / MGI
- abnormal locomotor behavior / MGI
- thymus hypoplasia / MGI
- increased activated T cell number / MGI
- abnormal hair texture / MGI
- increased IgE level / MGI
- increased erythroid progenitor cell number / MGI
- increased anti-nuclear antigen antibody level / MGI
- decreased B cell number / MGI
- decreased double-positive T cell number / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- decreased memory T cell number / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased plasma cell number / MGI
- abnormal B cell activation / MGI
- abnormal mononuclear cell morphology / MGI
- increased IgG1 level / MGI
MGI phenotypes (gene matching)
- increased neutrophil cell number / MGI
- increased granulocyte number / MGI
- abnormal sex gland morphology / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- weight loss / MGI
- abnormal locomotor behavior / MGI
- thymus hypoplasia / MGI
- abnormal T cell activation / MGI
- increased activated T cell number / MGI
- liver inflammation / MGI
- abnormal hair texture / MGI
- premature death / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- increased IgE level / MGI
- abnormal lymphocyte morphology / MGI
- abnormal immune system organ morphology / MGI
- increased erythroid progenitor cell number / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to autoimmune hemolytic anemia / MGI
- decreased regulatory T cell number / MGI
- abnormal T cell clonal deletion / MGI
- decreased B cell number / MGI
- decreased double-positive T cell number / MGI
- decreased T cell proliferation / MGI
- abnormal response to transplant / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- decreased memory T cell number / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased plasma cell number / MGI
- abnormal marginal zone B cell morphology / MGI
- abnormal B cell activation / MGI
- abnormal mononuclear cell morphology / MGI
- increased IgG1 level / MGI
Literature references
- Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.;Suzuki H, Kündig T M, Furlonger C, Wakeham A, Timms E, Matsuyama T, Schmits R, Simard J J, Ohashi P S, Griesser H, ;1995;Science (New York, N.Y.);268;1472-6; 7770771
- Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain.;Suzuki H, Duncan G S, Takimoto H, Mak T W, ;1997;The Journal of experimental medicine;185;499-505; 9053450
- Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo.;Suzuki H, Zhou Y W, Kato M, Mak T W, Nakashima I, ;1999;The Journal of experimental medicine;190;1561-72; 10587347