IMPC phenotypes (gene matching)
B6.129P2-Lcn2tm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:06368 |
| International strain name | B6.129P2-Lcn2tm1Mak/Cnbc |
| Alternative name | Lcn 2 C57Bl 6 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Lcn2tm1Mak |
| Gene/Transgene symbol | Lcn2 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Mak Lab, Campbell Family Breast Cancer reseach Institute |
| Genetic information | Lipocalin 2, Targeted (knock-out), Insertion, Intragenic deletion |
| Phenotypic information | Iron-trafficking protein involved in multiple processes such as innate immunity and cancer development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. |
| Breeding history | Pure C57BL/6, backcrossed 10 times. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous 0 |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased brown adipose tissue amount / MGI
- increased white adipose tissue amount / MGI
- increased circulating LDL cholesterol level / MGI
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- increased monocyte cell number / MGI
- abnormal erythropoiesis / MGI
- increased bone marrow cell number / MGI
- spleen hyperplasia / MGI
- thymus hyperplasia / MGI
- abnormal myelopoiesis / MGI
- reduced female fertility / MGI
- increased circulating insulin level / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal mast cell physiology / MGI
- increased hematocrit / MGI
- hepatic steatosis / MGI
- increased heart weight / MGI
- increased liver weight / MGI
- no phenotypic analysis / MGI
- increased erythrocyte cell number / MGI
- increased erythroid progenitor cell number / MGI
- thrombocytopenia / MGI
- increased kidney weight / MGI
- decreased adiponectin level / MGI
- increased spleen weight / MGI
- increased lymphocyte cell number / MGI
- increased B cell number / MGI
- sepsis / MGI
- increased circulating cholesterol level / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- renal/urinary system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased macrophage cell number / MGI
- increased mean corpuscular hemoglobin / MGI
- increased susceptibility to diet-induced obesity / MGI
- decreased apoptosis / MGI
- increased fat cell size / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased splenocyte number / MGI
- increased liver triglyceride level / MGI
- decreased thymocyte apoptosis / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- myeloid hyperplasia / MGI
- impaired adaptive thermogenesis / MGI
- increased erythroblast number / MGI
- increased fasted circulating glucose level / MGI
Literature references
- Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.;Berger Thorsten, Togawa Atsushi, Duncan Gordon S, Elia Andrew J, You-Ten Annick, Wakeham Andrew, Fong Hannah E H, Cheung Carol C, Mak Tak W, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;1834-9; 16446425
- Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.;Berger Thorsten, Cheung Carol C, Elia Andrew J, Mak Tak W, ;2010;Proceedings of the National Academy of Sciences of the United States of America;107;2995-3000; 20133630