C57BL/6N-Atp2a2tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:06358
International strain nameC57BL/6N-Atp2a2tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0714_3_B04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAtp2a2tm1a(EUCOMM)Hmgu
Gene/Transgene symbolAtp2a2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0714_3_B04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • increased fasting circulating glucose level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased mean platelet volume / IMPC
MGI phenotypes (gene matching)
  • abnormal vascular development / MGI
  • abnormal heart shape / MGI
  • esophageal epithelium hyperplasia / MGI
  • toenail hyperkeratosis / MGI
  • hyperkeratosis / MGI
  • decreased body weight / MGI
  • impaired righting response / MGI
  • cardiac hypertrophy / MGI
  • decreased embryo size / MGI
  • decreased litter size / MGI
  • increased tumor incidence / MGI
  • increased skin papilloma incidence / MGI
  • premature death / MGI
  • abnormal blood circulation / MGI
  • heart left ventricle hypertrophy / MGI
  • dilated heart left ventricle / MGI
  • dilated heart right ventricle / MGI
  • increased heart weight / MGI
  • decreased systemic arterial blood pressure / MGI
  • fatigue / MGI
  • thick ventricular wall / MGI
  • cardiac fibrosis / MGI
  • increased esophageal papilloma incidence / MGI
  • abnormal locomotor activation / MGI
  • aorta coarctation / MGI
  • abnormal vascular endothelial cell migration / MGI
  • abnormal physiological neovascularization / MGI
  • increased left ventricle diastolic pressure / MGI
  • decreased left ventricle systolic pressure / MGI
  • pulmonary edema / MGI
  • abnormal vascular endothelial cell physiology / MGI
  • abnormal cardiac muscle relaxation / MGI
  • increased squamous cell carcinoma incidence / MGI
  • abnormal calcium ion homeostasis / MGI
  • increased response of heart to induced stress / MGI
  • decreased cardiac muscle contractility / MGI
  • cachexia / MGI
  • bradykinesia / MGI
  • lethargy / MGI
  • stomach epithelial hyperplasia / MGI
  • decreased ventricle muscle contractility / MGI
  • decreased angiogenesis / MGI
  • cardiac interstitial fibrosis / MGI
  • congestive heart failure / MGI
  • abnormal osteoclast differentiation / MGI
  • penis prolapse / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • ventricular septal defect / MGI
  • atrial septal defect / MGI
  • ascending aorta hypoplasia / MGI
  • thin ventricle myocardium compact layer / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • increased tongue papilloma incidence / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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