C57BL/6NTac-Lamb3tm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:06294
Citation informationRRID:IMSR_EM:06294 

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International strain nameC57BL/6NTac-Lamb3tm1a(KOMP)Wtsi/H
Alternative nameEPD0079_6_C12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolLamb3tm1a(KOMP)Wtsi
Gene/Transgene symbolLamb3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0079_6_C12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal skin morphology / IMPC
  • abnormal tooth morphology / IMPC
MGI phenotypes (gene matching)
  • abnormal tongue epithelium morphology / MGI
  • blistering / MGI
  • decreased body weight / MGI
  • abnormal skin morphology / MGI
  • abnormal nasopharynx morphology / MGI
  • abnormal oropharynx morphology / MGI
  • abnormal skin appearance / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • abnormal epidermal-dermal junction morphology / MGI
  • dermal-epidermal separation / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
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