C57BL/6N-Atm1Brd Espntm1a(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:06288
International strain nameC57BL/6N-Atm1Brd Espntm1a(EUCOMM)Wtsi/WtsiH
Alternative nameEPD0409_1_A08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolEspntm1a(EUCOMM)Wtsi
Gene/Transgene symbolEspn
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0409_1_A08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac
Breeding at archiving centreFrozen samples received. No breeding at archiving centre. Due to the possible presence of C57BL/6N-Atm1Brd/a, may produce agouti pups.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • absent pinna reflex / IMPC
  • lipid deposition / IMPC
IMPC phenotypes (gene matching)
  • lipid deposition / IMPC
  • absent pinna reflex / IMPC
MGI phenotypes (allele matching)
  • increased mean corpuscular hemoglobin / MGI
  • increased hemoglobin content / MGI
  • absent pinna reflex / MGI
MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • abnormal inner ear vestibule morphology / MGI
  • abnormal organ of Corti morphology / MGI
  • organ of Corti degeneration / MGI
  • abnormal stria vascularis morphology / MGI
  • tremors / MGI
  • abnormal nursing / MGI
  • abnormal stationary movement / MGI
  • abnormal locomotor behavior / MGI
  • circling / MGI
  • bidirectional circling / MGI
  • abnormal gait / MGI
  • decreased grooming behavior / MGI
  • impaired swimming / MGI
  • impaired balance / MGI
  • abnormal reflex / MGI
  • deafness / MGI
  • abnormal cochlear hair cell morphology / MGI
  • abnormal endocochlear potential / MGI
  • head shaking / MGI
  • decreased vertical activity / MGI
  • abnormal cochlear ganglion morphology / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal otolithic membrane morphology / MGI
  • abnormal response to novelty / MGI
  • abnormal tectorial membrane morphology / MGI
  • detached tectorial membrane / MGI
  • abnormal defecation / MGI
  • abnormal ear physiology / MGI
  • vestibular hair cell degeneration / MGI
  • vestibular saccular macula degeneration / MGI
  • abnormal utricular macula morphology / MGI
  • cochlear hair cell degeneration / MGI
  • cochlear inner hair cell degeneration / MGI
  • cochlear outer hair cell degeneration / MGI
  • abnormal crista ampullaris neuroepithelium morphology / MGI
  • absent cochlear microphonics / MGI
  • absent cochlear nerve compound action potential / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • decreased cochlear hair cell stereocilia number / MGI
  • short cochlear hair cell stereocilia / MGI
  • thin cochlear hair cell stereocilia / MGI
  • abnormal inner hair cell stereociliary bundle morphology / MGI
  • pillar cell degeneration / MGI
  • abnormal vestibular system physiology / MGI
  • absent linear vestibular evoked potential / MGI
  • reduced linear vestibular evoked potential / MGI
  • increased mean corpuscular hemoglobin / MGI
  • increased hemoglobin content / MGI
  • abnormal hearing electrophysiology / MGI
  • absent pinna reflex / MGI
  • retropulsion / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
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MTA will be issued after an order has been submitted.

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