C57BL/6NTac-Gatmtm1a(KOMP)Wtsi/Ieg

Status

Available to order

EMMA IDEM:06283
International strain nameC57BL/6NTac-Gatmtm1a(KOMP)Wtsi/Ieg
Alternative nameEPD0218_5_E08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGatmtm1a(KOMP)Wtsi
Gene/Transgene symbolGatm
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from KOMP ES clone EPD0218_5_E08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6NTac/USA
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • prolonged RR interval / IMPC
  • decreased red blood cell distribution width / IMPC
  • male infertility / IMPC
  • decreased locomotor activity / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • decreased respiratory quotient / IMPC
  • thrombocytopenia / IMPC
  • decreased grip strength / IMPC
  • increased circulating amylase level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • prolonged QRS complex duration / IMPC
  • prolonged QT interval / IMPC
  • decreased prepulse inhibition / IMPC
  • female infertility / IMPC
  • decreased circulating cholesterol level / IMPC
  • abnormal behavior / IMPC
  • decreased exploration in new environment / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • cardiovascular system phenotype / IMPC
  • decreased food intake / IMPC
  • increased heart rate variability / IMPC
  • increased circulating potassium level / IMPC
  • abnormal QT variability / IMPC
  • prolonged ST segment / IMPC
  • decreased heart rate / IMPC
  • abnormal sinus arrhythmia / IMPC
MGI phenotypes (gene matching)
  • scoliosis / MGI
  • abnormal testis morphology / MGI
  • abnormal spermatogenesis / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • hypoactivity / MGI
  • abnormal eating behavior / MGI
  • decreased white adipose tissue amount / MGI
  • male infertility / MGI
  • female infertility / MGI
  • abnormal glucose homeostasis / MGI
  • decreased susceptibility to hepatic steatosis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating insulin level / MGI
  • abnormal gluconeogenesis / MGI
  • hypotonia / MGI
  • diarrhea / MGI
  • decreased circulating cholesterol level / MGI
  • improved glucose tolerance / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • immune system phenotype / MGI
  • decreased circulating glucose level / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • decreased circulating leptin level / MGI
  • decreased body mass index / MGI
  • increased susceptibility to induced colitis / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • abnormal enterocyte proliferation / MGI
  • increased enterocyte apoptosis / MGI
  • decreased liver triglyceride level / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • decreased total body fat amount / MGI
  • decreased creatine level / MGI
  • increased susceptibility to weight loss / MGI
  • abnormal urine amino acid level / MGI
  • decreased urine creatinine level / MGI
  • abnormal duodenum crypts of Lieberkuhn morphology / MGI
  • decreased colon length / MGI
  • increased adipocyte glucose uptake / MGI
  • increased muscle cell glucose uptake / MGI
  • decreased urine creatine level / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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