IMPC phenotypes (gene matching)
C57BL/6NTac-Roratm1a(EUCOMM)Wtsi/Ieg
| Status | Available to order |
| EMMA ID | EM:06273 |
| International strain name | C57BL/6NTac-Roratm1a(EUCOMM)Wtsi/Ieg |
| Alternative name | EPD0157_5_B01 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Roratm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Rora |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0157_5_B01. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTacUSA, wild-type C57BL/6NTacUSA |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased circulating HDL cholesterol level / MGI
- abnormal vasoconstriction / MGI
- absent duvet hair / MGI
- sparse hair / MGI
- retarded hair growth / MGI
- tremors / MGI
- hindlimb paralysis / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal cerebellum morphology / MGI
- small cerebellum / MGI
- abnormal cerebellar foliation / MGI
- abnormal cerebellum external granule cell layer morphology / MGI
- abnormal cerebellar Purkinje cell layer / MGI
- Purkinje cell degeneration / MGI
- abnormal Purkinje cell morphology / MGI
- decreased Purkinje cell number / MGI
- delaminated Purkinje cell layer / MGI
- ectopic Purkinje cell / MGI
- abnormal cerebellar granule layer morphology / MGI
- absent cerebellar granule layer / MGI
- abnormal cerebellar molecular layer / MGI
- thin cerebellar molecular layer / MGI
- decreased body size / MGI
- abnormal maternal nurturing / MGI
- ataxia / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- abnormal spatial learning / MGI
- limb grasping / MGI
- impaired righting response / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- abnormal vasodilation / MGI
- abnormal immune system physiology / MGI
- lung inflammation / MGI
- reduced female fertility / MGI
- abnormal estrous cycle / MGI
- abnormal olfaction / MGI
- abnormal motor capabilities/coordination/movement / MGI
- abnormal lipid homeostasis / MGI
- abnormal brain morphology / MGI
- abnormal fertility/fecundity / MGI
- abnormal respiratory mucosa morphology / MGI
- abnormal lung compliance / MGI
- abnormal macrophage physiology / MGI
- increased IgE level / MGI
- abnormal sexual interaction / MGI
- abnormal immune system organ morphology / MGI
- small olfactory bulb / MGI
- ectopic cerebellar granule cells / MGI
- abnormal motor learning / MGI
- abnormal excitatory postsynaptic currents / MGI
- no phenotypic analysis / MGI
- abnormal external female genitalia morphology / MGI
- abnormal nervous system physiology / MGI
- spleen atrophy / MGI
- thymus atrophy / MGI
- abnormal radial glial cell morphology / MGI
- abnormal inferior olivary complex morphology / MGI
- abnormal female reproductive system physiology / MGI
- abnormal hormone level / MGI
- abnormal cerebellar granule cell morphology / MGI
- abnormal brain interneuron morphology / MGI
- abnormal limb posture / MGI
- abnormal synaptic glutamate release / MGI
- decreased mean systemic arterial blood pressure / MGI
- decreased circulating cholesterol level / MGI
- atherosclerotic lesions / MGI
- increased susceptibility to atherosclerosis / MGI
- immune system phenotype / MGI
- taste/olfaction phenotype / MGI
- increased angiogenesis / MGI
- thin cerebellar granule layer / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- abnormal Purkinje cell differentiation / MGI
- increased interleukin-1 secretion / MGI
- decreased cerebellar granule cell number / MGI
- delayed estrous cycle / MGI
- prolonged estrus / MGI
- prolonged metestrus / MGI
- reduced cerebellar foliation / MGI
- abnormal olfactory bulb granule cell morphology / MGI
- abnormal olfactory bulb layer morphology / MGI
- abnormal olfactory bulb external plexiform layer morphology / MGI
- abnormal olfactory bulb glomerular layer morphology / MGI
- abnormal olfactory bulb granule cell layer morphology / MGI
- abnormal olfactory bulb internal plexiform layer morphology / MGI
- abnormal olfactory bulb mitral cell layer morphology / MGI
- abnormal cerebellar layer morphology / MGI
- absent cerebellar granule cells / MGI
- abnormal neuron proliferation / MGI
- abnormal cerebellum deep nucleus morphology / MGI
- decreased grip strength / MGI
- abnormal olfactory bulb outer nerve layer morphology / MGI
- lethality at weaning, incomplete penetrance / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- abnormal cochlear VIII nucleus morphology / MGI
- increased noradrenaline level / MGI
- decreased cerebellar granule cell precursor proliferation / MGI
- decreased taurine level / MGI
- decreased gamma-aminobutyric acid level / MGI
- decreased aspartic acid level / MGI