- increased leukocyte cell number / MGI
- increased monocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- abnormal erythropoiesis / MGI
- increased bone marrow cell number / MGI
- increased granulocyte number / MGI
- small spleen / MGI
- increased thymocyte number / MGI
- decreased thymocyte number / MGI
- reddish skin / MGI
- abnormal skin condition / MGI
- scaly skin / MGI
- dermatitis / MGI
- flaky skin / MGI
- spontaneous skin ulceration / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- hyperkeratosis / MGI
- decreased body weight / MGI
- decreased body size / MGI
- anemia / MGI
- abnormal myelopoiesis / MGI
- postnatal growth retardation / MGI
- abnormal humoral immune response / MGI
- decreased IgA level / MGI
- abnormal T cell activation / MGI
- increased activated T cell number / MGI
- autoimmune response / MGI
- acanthosis / MGI
- premature death / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal granulocyte morphology / MGI
- abnormal macrophage physiology / MGI
- increased IgG level / MGI
- increased IgA level / MGI
- increased IgE level / MGI
- chronic inflammation / MGI
- abnormal keratinocyte morphology / MGI
- increased anti-insulin autoantibody level / MGI
- increased pre-B cell number / MGI
- spleen atrophy / MGI
- thymus atrophy / MGI
- dry skin / MGI
- increased anti-nuclear antigen antibody level / MGI
- decreased regulatory T cell number / MGI
- decreased B cell number / MGI
- abnormal cell differentiation / MGI
- decreased double-negative T cell number / MGI
- increased double-positive T cell number / MGI
- decreased double-positive T cell number / MGI
- decreased B cell proliferation / MGI
- decreased T cell proliferation / MGI
- increased B cell proliferation / MGI
- increased T cell proliferation / MGI
- increased macrophage cell number / MGI
- abnormal cell physiology / MGI
- abnormal T cell number / MGI
- increased T cell apoptosis / MGI
- increased memory T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased single-positive T cell number / MGI
- abnormal granulocyte differentiation / MGI
- decreased Peyer's patch number / MGI
- small Peyer's patches / MGI
- decreased follicular B cell number / MGI
- abnormal marginal zone B cell morphology / MGI
- decreased marginal zone B cell number / MGI
- increased pro-B cell number / MGI
- decreased B-2 B cell number / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased IgG2b level / MGI
- increased circulating tumor necrosis factor level / MGI
- increased circulating interleukin-17 level / MGI
- increased circulating interleukin-1 alpha level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- decreased transitional stage T2 B cell number / MGI
- abnormal circulating cytokine level / MGI
- increased activation-induced B cell apoptosis / MGI
- decreased CD4-positive, alpha-beta memory T cell number / MGI
- postnatal lethality, complete penetrance / MGI
STOCK Nfkbiatm1Kbp Tg(KRT14-cre)1Cgn/Ieg
Status | Available to order |
EMMA ID | EM:06271 |
International strain name | STOCK Nfkbiatm1Kbp Tg(KRT14-cre)1Cgn/Ieg |
Alternative name | K14cre Ikba |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(KRT14-cre)1Cgn, Nfkbiatm1Kbp |
Gene/Transgene symbol | Tg(KRT14-cre)1Cgn, Nfkbia |
Information from provider
Provider | Rudolf Rupec |
Provider affiliation | Derma AG |
Genetic information | Inducible skin specific deletion of Nfkbia (promoter region containing essential regulatory NF-kappaB binding sites, the core promoter, and the first two exons) with cre-loxP system. Cre-expression linked to keratin 14. |
Phenotypic information | Persistent skin inflammation; psoriasis like. |
References |
|
Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | heterozygous C57BL/6N, wild-type C57BL/6N |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Nasopharyngeal carcinoma / Orphanet_150
- Hypohidrotic ectodermal dysplasia with immunodeficiency / Orphanet_98813
MGI phenotypes (gene matching)
Literature references
- Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin.;Rebholz Bernd, Haase Ingo, Eckelt Birgit, Paxian Stephan, Flaig Michael J, Ghoreschi Kamran, Nedospasov Sergei A, Mailhammer Reinhard, Debey-Pascher Svenja, Schultze Joachim L, Weindl Günther, Förster Irmgard, Huss Ralf, Stratis Athanasios, Ruzicka Thomas, Röcken Martin, Pfeffer Klaus, Schmid Roland M, Rupec Rudolf A, ;2007;Immunity;27;296-307; 17692539
- Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha.;Rupec Rudolf A, Jundt Franziska, Rebholz Bernd, Eckelt Birgit, Weindl Günther, Herzinger Thomas, Flaig Michael J, Moosmann Sabine, Plewig Gerd, Dörken Bernd, Förster Irmgard, Huss Ralf, Pfeffer Klaus, ;2005;Immunity;22;479-91; 15845452
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