C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/Biat
| Status | Available to order |
| EMMA ID | EM:06230 |
| International strain name | C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/Biat |
| Alternative name | PbBAC-MCM14 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Pbsn-cre/Esr1*)14Abch |
| Gene/Transgene symbol | Tg(Pbsn-cre/Esr1*)14Abch |
Information from provider
| Provider | Andreas Birbach |
| Provider affiliation | Vascular Biology, Medical University of Vienna |
| Genetic information | BAC RP23-456A6 from CHORI was modified by ET cloning. MerCreMer cDNA was inserted into the ATG start codon of the murine probasin gene. |
| Phenotypic information | PbBAC-MCM14 is one of two strains created by our group expressing the tamoxifen-inducible Cre protein MErCreMer specifically in the prostate epithelium. Expression of MerCreMer is specific to the androgen-dependent luminal prostate epithelium, seen in all 4 lobes of the murine prostate, and was shown to be functional, i.e. lead to Cre-mediated DNA excision in a dose-dependent-manner upon tamoxifen injection. |
| Breeding history | Mice were crossed with C57BL/6 mice or reporter mice on a C57BL/6 background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Literature references
- A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostate.;Birbach Andreas, Casanova Emilio, Schmid Johannes A, ;2009;Genesis (New York, N.Y. : 2000);47;757-64; 19830822