C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/Biat
| Status | Available to order |
| EMMA ID | EM:06230 |
| Citation information | RRID:IMSR_EM:06230 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/Biat |
| Alternative name | PbBAC-MCM14 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Pbsn-cre/Esr1*)14Abch |
| Gene/Transgene symbol | Tg(Pbsn-cre/Esr1*)14Abch |
Information from provider
| Provider | Andreas Birbach |
| Provider affiliation | Vascular Biology, Medical University of Vienna |
| Genetic information | BAC RP23-456A6 from CHORI was modified by ET cloning. MerCreMer cDNA was inserted into the ATG start codon of the murine probasin gene. |
| Phenotypic information | PbBAC-MCM14 is one of two strains created by our group expressing the tamoxifen-inducible Cre protein MErCreMer specifically in the prostate epithelium. Expression of MerCreMer is specific to the androgen-dependent luminal prostate epithelium, seen in all 4 lobes of the murine prostate, and was shown to be functional, i.e. lead to Cre-mediated DNA excision in a dose-dependent-manner upon tamoxifen injection. |
| Breeding history | Mice were crossed with C57BL/6 mice or reporter mice on a C57BL/6 background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Literature references
- A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostate.;Birbach Andreas, Casanova Emilio, Schmid Johannes A, ;2009;Genesis (New York, N.Y. : 2000);47;757-64; 19830822