STOCK Atrtm2Ofc/Cnbc

Status

Available to order

EMMA IDEM:06220
International strain nameSTOCK Atrtm2Ofc/Cnbc
Alternative nameAtr
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolAtrtm2Ofc
Gene/Transgene symbolAtr

Information from provider

ProviderOskar Fernandez-Capetillo
Provider affiliationMolecular Oncology, Centro Nacional de Investigaciones Oncologicas (CNIO)
Genetic informationExons 8 through 10 were replaced with the corresponding wt human sequence including corresponding introns.
Phenotypic informationA mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. PubMed ID: 19620979.
Breeding historyChimeras were crossed with C57BL/6J females for germ line transmission testing. Currently maintained by crossing homozygous mice.
References
  • A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.;Murga Matilde, Bunting Samuel, Montaña Maria F, Soria Rebeca, Mulero Francisca, Cañamero Marta, Lee Youngsoo, McKinnon Peter J, Nussenzweig Andre, Fernandez-Capetillo Oscar, ;2009;Nature genetics;41;891-8; 19620979
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous C57BL/6J

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased circulating glucose level / IMPC
  • abnormal spinal cord morphology / IMPC
  • embryonic lethality prior to organogenesis / IMPC
  • increased fasting circulating glucose level / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased heart weight / IMPC
MGI phenotypes (allele matching)
  • growth/size/body region phenotype / MGI
  • craniofacial phenotype / MGI
MGI phenotypes (gene matching)
  • osteoporosis / MGI
  • abnormal fontanelle morphology / MGI
  • malocclusion / MGI
  • kyphosis / MGI
  • decreased bone marrow cell number / MGI
  • decreased hair follicle number / MGI
  • microcephaly / MGI
  • decreased brain size / MGI
  • thin epidermis / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • abnormal placenta morphology / MGI
  • abnormal oogenesis / MGI
  • neoplasm / MGI
  • increased tumor incidence / MGI
  • abnormal coat/hair pigmentation / MGI
  • premature death / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • decreased brain weight / MGI
  • abnormal astrocyte morphology / MGI
  • absent corpus callosum / MGI
  • abnormal nose morphology / MGI
  • abnormal bone marrow morphology / MGI
  • micrognathia / MGI
  • abnormal cranial suture morphology / MGI
  • abnormal cell cycle / MGI
  • decreased liver weight / MGI
  • premature aging / MGI
  • spontaneous chromosome breakage / MGI
  • induced chromosome breakage / MGI
  • small thoracic cavity / MGI
  • decreased mitotic index / MGI
  • absent oocytes / MGI
  • abnormal hematopoietic stem cell morphology / MGI
  • decreased testis weight / MGI
  • decreased ovary weight / MGI
  • decreased spleen weight / MGI
  • decreased thymus weight / MGI
  • cachexia / MGI
  • pancytopenia / MGI
  • growth/size/body region phenotype / MGI
  • craniofacial phenotype / MGI
  • decreased lung weight / MGI
  • increased apoptosis / MGI
  • early cellular replicative senescence / MGI
  • abnormal DNA replication / MGI
  • increased cellular sensitivity to methylmethanesulfonate / MGI
  • increased cellular sensitivity to ultraviolet irradiation / MGI
  • proportional dwarf / MGI
  • abnormal primary ovarian follicle morphology / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal head shape / MGI
  • abnormal head size / MGI
  • increased fibroblast apoptosis / MGI
  • sloping forehead / MGI

Literature references

  • A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.;Murga Matilde, Bunting Samuel, Montaña Maria F, Soria Rebeca, Mulero Francisca, Cañamero Marta, Lee Youngsoo, McKinnon Peter J, Nussenzweig Andre, Fernandez-Capetillo Oscar, ;2009;Nature genetics;41;891-8; 19620979

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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