MGI phenotypes (allele matching)
B6.129-Sertad1tm1Srn/Cnbc
| Status | Available to order |
| EMMA ID | EM:06217 |
| International strain name | B6.129-Sertad1tm1Srn/Cnbc |
| Alternative name | Sertad1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Sertad1tm1Srn |
| Gene/Transgene symbol | Sertad1 |
Information from provider
| Provider | Manuel Serrano |
| Provider affiliation | Molecular Oncology, CNIO (Spanish National Cancer Research Centre) |
| Genetic information | Exon 2 was replaced with a neo cassette. The absence of transcript expression was confirmed by Northern blot analysis on ES cell extracts. |
| Phenotypic information | Sei1 (Sertad1) null mice are viable, do not present overt pathologies, have a normal lifespan, and have a normal susceptibility to spontaneous and chemically-induced cancer. Sei1 is highly expressed in pancreatic islets compared to other tissues. Interestingly, Sei1-null mice present lower number of islets, decreased beta-cell area, impaired insulin secretion, and glucose intolerance. |
| Breeding history | The Sei1 mouse line has been backcrossed more than 9 generations to C57BL/6J. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1.;Fernandez-Marcos Pablo J, Pantoja Cristina, Gonzalez-Rodriguez Agueda, Martin Nicholas, Flores Juana M, Valverde Angela M, Hara Eiji, Serrano Manuel, ;2010;PloS one;5;e8744; 20090907