C57BL/6NTac-Ctsdtm1a(EUCOMM)Wtsi/Ics

Status

Available to order

EMMA IDEM:06216
International strain nameC57BL/6NTac-Ctsdtm1a(EUCOMM)Wtsi/Ics
Alternative nameEPD0105_1_A12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCtsdtm1a(EUCOMM)Wtsi
Gene/Transgene symbolCtsd
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0105_1_A12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France
Animals used for archivingheterozygous C57BL/6N Tac, wild-type C57BL/6N Tac
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating aspartate transaminase level / IMPC
  • corneal opacity / IMPC
  • decreased hematocrit / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal microglial cell morphology / MGI
  • abnormal hair cycle / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • weakness / MGI
  • hippocampal neuron degeneration / MGI
  • decreased body weight / MGI
  • abnormal retina morphology / MGI
  • ataxia / MGI
  • abnormal apoptosis / MGI
  • thymus hypoplasia / MGI
  • abnormal antigen presentation / MGI
  • deafness / MGI
  • blindness / MGI
  • seizures / MGI
  • premature death / MGI
  • abnormal spleen white pulp morphology / MGI
  • abnormal ileum morphology / MGI
  • tonic seizures / MGI
  • abnormal cochlear ganglion morphology / MGI
  • neuron degeneration / MGI
  • axonal dystrophy / MGI
  • thymus atrophy / MGI
  • decreased lymphocyte cell number / MGI
  • abnormal thrombosis / MGI
  • lysosomal protein accumulation / MGI
  • decreased double-positive T cell number / MGI
  • cachexia / MGI
  • bradykinesia / MGI
  • cellular phenotype / MGI
  • retinal photoreceptor degeneration / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • abnormal stomach wall morphology / MGI
  • lethality at weaning, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).