C57BL/6N-Map3k7tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:06159
International strain nameC57BL/6N-Map3k7tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0765_1_B11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolMap3k7tm1a(EUCOMM)Wtsi
Gene/Transgene symbolMap3k7
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0765_1_B11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • abnormal lens morphology / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
MGI phenotypes (gene matching)
  • abnormal vascular development / MGI
  • abnormal heart morphology / MGI
  • abnormal vascular regression / MGI
  • microcephaly / MGI
  • short tail / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal blood vessel morphology / MGI
  • decreased embryo size / MGI
  • edema / MGI
  • pericardial edema / MGI
  • hemorrhage / MGI
  • small heart / MGI
  • abnormal myocardial trabeculae morphology / MGI
  • abnormal pharyngeal arch artery morphology / MGI
  • abnormal vitelline vasculature morphology / MGI
  • thin myocardium compact layer / MGI
  • abnormal vitelline vascular remodeling / MGI
  • abnormal dorsal aorta morphology / MGI
  • abnormal vascular smooth muscle morphology / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • absent fibroblast proliferation / MGI
  • embryo tissue necrosis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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