B6D2-Tg(KRT14-SFN)44Odo/Cnrm
| Status | Available to order |
| EMMA ID | EM:06111 |
| Citation information | RRID:IMSR_EM:06111 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6D2-Tg(KRT14-SFN)44Odo/Cnrm |
| Alternative name | TG/K14-14,3,3sigma |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT14-SFN)44Odo |
| Gene/Transgene symbol | Tg(KRT14-SFN)44Odo |
Information from provider
| Provider | Teresa Odorisio |
| Provider affiliation | Lab. Biologia Molecolare e Cellulare, Istituto Dermopatico dell'Immacolata |
| Genetic information | Transgenic line overexpressing the human stratifin (14-3-3sigma) gene under the control of the keratin 14 (K14) promoter. |
| Phenotypic information | Adult transgenic mice show decreased epidermal thickness and hair follicle density, reduced number of proliferating keratinocytes and keratinocyte progenitor cells. |
| Breeding history | Mice have always been on a B6D2F1 background. Current generation is F19. Mice are currently bred as heterozygous, mating with B6D2F1 wt mice. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Impaired keratinocyte proliferative and clonogenic potential in transgenic mice overexpressing 14-3-3σ in the epidermis.;Cianfarani Francesca, Bernardini Silvia, De Luca Naomi, Dellambra Elena, Tatangelo Laura, Tiveron Cecilia, Niessen Carien M, Zambruno Giovanna, Castiglia Daniele, Odorisio Teresa, ;2011;The Journal of investigative dermatology;131;1821-9; 21654836