B6.129P2-Creb1tm2Gsc/Cnrm

Status

Available to order

EMMA IDEM:00611
Citation informationRRID:IMSR_EM:00611 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129P2-Creb1tm2Gsc/Cnrm
Alternative nameCREBnull
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCreb1tm2Gsc
Gene/Transgene symbolCreb1

Information from provider

ProviderGünther Schütz
Provider affiliationMolecular Biology of the Cell I, German Cancer Research Center
Genetic informationReplacement of part of the leucine zipper encoding sequence by a lacZ-neomycin cassette fusion.
References
  • Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein.;Rudolph D, Tafuri A, Gass P, Hämmerling G J, Arnold B, Schütz G, ;1998;Proceedings of the National Academy of Sciences of the United States of America;95;4481-6; 9539763

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal myogenesis / MGI
  • abnormal muscle regeneration / MGI
  • small superior cervical ganglion / MGI
  • abnormal stellate ganglion morphology / MGI
  • abnormal lung development / MGI
  • abnormal cued conditioning behavior / MGI
  • abnormal spatial learning / MGI
  • abnormal temporal memory / MGI
  • abnormal contextual conditioning behavior / MGI
  • reduced long term potentiation / MGI
  • postnatal lethality / MGI
  • abnormal CNS synaptic transmission / MGI
  • decreased vertical activity / MGI
  • abnormal single cell response / MGI
  • small lung / MGI
  • abnormal lung vasculature morphology / MGI
  • decreased fetal size / MGI
  • muscle phenotype / MGI
  • impaired lung alveolus development / MGI
  • decreased survivor rate / MGI
  • abnormal behavioral response to addictive substance / MGI
  • decreased behavioral withdrawal response / MGI
  • pale lung / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • abnormal circadian behavior phase / MGI

Literature references

  • Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein.;Rudolph D, Tafuri A, Gass P, Hämmerling G J, Arnold B, Schütz G, ;1998;Proceedings of the National Academy of Sciences of the United States of America;95;4481-6; 9539763

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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