C57BL/6NTac-Tg(ACTB-cre)3Mrt/H
| Status | Available to order |
| EMMA ID | EM:06107 |
| Citation information | RRID:IMSR_EM:06107 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Tg(ACTB-cre)3Mrt/H |
| Alternative name | C57BL/6NTac-Tg(ACTB-cre)3Mrt/H |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(ACTB-cre)3Mrt |
| Gene/Transgene symbol | Tg(ACTB-cre)3Mrt |
Information from provider
| Provider | Martin FRAY |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This transgene expresses cre recombinase under the control of a human beta-actin promoter, which is active in all embryonic cells at or before the blastocyst stage. The transgene was injected at Harwell into C57BL/6NTac oocytes and maintained on this background thereafter. |
| Phenotypic information | Ubiquitous cre expressor. No overt phenotype. To date, 100% effective cre deletion reported. |
| Breeding history | The transgene was injected at Harwell into C57BL/6NTac oocytes and maintained on this background thereafter. This strain is coisogenic on C57BL/6NTac. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTac males, wild-type C57BL/6NTac females |
| Breeding at archiving centre | The transgene was injected into C57BL/6NTac oocytes and maintained on this background thereafter. Heterozygous mice were used for archiving |
| Stage of embryos | 2-cell |
Literature references
- Analysis of Fgf8 gene function in vertebrate development.;Lewandoski M, Meyers E N, Martin G R, ;1997;Cold Spring Harbor symposia on quantitative biology;62;159-68; 9598348
- Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.;Löser Stephan, Gregory Lisa G, Zhang Youming, Schaefer Katrein, Walker Simone A, Buckley James, Denney Laura, Dean Charlotte H, Cookson William O C, Moffatt Miriam F, Lloyd Clare M, ;2017;The Journal of allergy and clinical immunology;139;1496-1507.e3; 27623174