C57BL/6NTac-Tg(ACTB-cre)3Mrt/H
| Status | Available to order |
| EMMA ID | EM:06107 |
| International strain name | C57BL/6NTac-Tg(ACTB-cre)3Mrt/H |
| Alternative name | C57BL/6NTac-Tg(ACTB-cre)3Mrt/H |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(ACTB-cre)3Mrt |
| Gene/Transgene symbol | Tg(ACTB-cre)3Mrt |
Information from provider
| Provider | Martin FRAY |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This transgene expresses cre recombinase under the control of a human beta-actin promoter, which is active in all embryonic cells at or before the blastocyst stage. The transgene was injected at Harwell into C57BL/6NTac oocytes and maintained on this background thereafter. |
| Phenotypic information | Ubiquitous cre expressor. No overt phenotype. To date, 100% effective cre deletion reported. |
| Breeding history | The transgene was injected at Harwell into C57BL/6NTac oocytes and maintained on this background thereafter. This strain is coisogenic on C57BL/6NTac. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTac, wild-type C57BL/6NTac |
| Breeding at archiving centre | The transgene was injected into C57BL/6NTac oocytes and maintained on this background thereafter. Heterozygous mice were used for archiving |
| Stage of embryos | 2-cell |
Literature references
- Analysis of Fgf8 gene function in vertebrate development.;Lewandoski M, Meyers E N, Martin G R, ;1997;Cold Spring Harbor symposia on quantitative biology;62;159-68; 9598348
- Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.;Löser Stephan, Gregory Lisa G, Zhang Youming, Schaefer Katrein, Walker Simone A, Buckley James, Denney Laura, Dean Charlotte H, Cookson William O C, Moffatt Miriam F, Lloyd Clare M, ;2017;The Journal of allergy and clinical immunology;139;1496-1507.e3; 27623174