IMPC phenotypes (gene matching)
B6.129P2-Nr3c2tm2.1Gsc/Cnrm
| Status | Available to order |
| EMMA ID | EM:00610 |
| International strain name | B6.129P2-Nr3c2tm2.1Gsc/Cnrm |
| Alternative name | MRnull |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nr3c2tm2.1Gsc |
| Gene/Transgene symbol | Nr3c2 |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | The Nr3c2 (MR) null mutation was generated by cre-mediated recombination of a conditional Nr3c2 allele, which was produced by homologous recombination. In this allele the complete exon 3, encoding the first Zn-finger of the DNA binding domain, was removed. |
| Phenotypic information | Death in 2 weeks after birth due to intense renal salt loss. Mimics pseudohypoaldosteronism. |
| Breeding history | Backcrossed to C57BL/6, N10. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Renal pseudohypoaldosteronism type 1 / Orphanet_171871
MGI phenotypes (allele matching)
- postnatal lethality / MGI
MGI phenotypes (gene matching)
- decreased body weight / MGI
- weight loss / MGI
- dehydration / MGI
- abnormal ion homeostasis / MGI
- postnatal lethality / MGI
- increased hematocrit / MGI
- increased circulating aldosterone level / MGI
- abnormal juxtaglomerular apparatus morphology / MGI
- increased circulating renin level / MGI
- abnormal renal glomerulus morphology / MGI
- renal/urinary system phenotype / MGI
- increased renin activity / MGI
- increased circulating potassium level / MGI
- decreased circulating sodium level / MGI
- increased urine sodium level / MGI
- abnormal renal sodium reabsorbtion / MGI
- hypovolemia / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal macula densa morphology / MGI
- abnormal juxtaglomerular cell morphology / MGI
- abnormal extraglomerular mesangial cell morphology / MGI
- abnormal renal sodium ion transport / MGI
Literature references
- Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity.;Berger Stefan, Wolfer David P, Selbach Oliver, Alter Heike, Erdmann Gitta, Reichardt Holger M, Chepkova Aisa N, Welzl Hans, Haas Helmut L, Lipp Hans-Peter, Schütz Günther, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;195-200; 16368758
- The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses.;Hoppmann J, Perwitz N, Meier B, Fasshauer M, Hadaschik D, Lehnert H, Klein J, ;2010;The Journal of endocrinology;204;153-64; 19939912