IMPC phenotypes (gene matching)
B6.129P2-Nr3c2tm2.1Gsc/Cnrm
| Status | Available to order |
| EMMA ID | EM:00610 |
| Citation information | RRID:IMSR_EM:00610 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Nr3c2tm2.1Gsc/Cnrm |
| Alternative name | MRnull |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nr3c2tm2.1Gsc |
| Gene/Transgene symbol | Nr3c2 |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | The Nr3c2 (MR) null mutation was generated by cre-mediated recombination of a conditional Nr3c2 allele, which was produced by homologous recombination. In this allele the complete exon 3, encoding the first Zn-finger of the DNA binding domain, was removed. |
| Phenotypic information | Death in 2 weeks after birth due to intense renal salt loss. Mimics pseudohypoaldosteronism. |
| Breeding history | Backcrossed to C57BL/6, N10. |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Renal pseudohypoaldosteronism type 1 / Orphanet_171871
MGI phenotypes (allele matching)
- postnatal lethality / MGI
MGI phenotypes (gene matching)
- decreased body weight / MGI
- weight loss / MGI
- dehydration / MGI
- abnormal ion homeostasis / MGI
- postnatal lethality / MGI
- increased hematocrit / MGI
- increased circulating aldosterone level / MGI
- abnormal juxtaglomerular apparatus morphology / MGI
- increased circulating renin level / MGI
- abnormal renal glomerulus morphology / MGI
- renal/urinary system phenotype / MGI
- increased renin activity / MGI
- increased circulating potassium level / MGI
- decreased circulating sodium level / MGI
- increased urine sodium level / MGI
- abnormal renal sodium reabsorbtion / MGI
- hypovolemia / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal macula densa morphology / MGI
- abnormal juxtaglomerular cell morphology / MGI
- abnormal extraglomerular mesangial cell morphology / MGI
- abnormal renal sodium ion transport / MGI
Literature references
- Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity.;Berger Stefan, Wolfer David P, Selbach Oliver, Alter Heike, Erdmann Gitta, Reichardt Holger M, Chepkova Aisa N, Welzl Hans, Haas Helmut L, Lipp Hans-Peter, Schütz Günther, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;195-200; 16368758
- The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses.;Hoppmann J, Perwitz N, Meier B, Fasshauer M, Hadaschik D, Lehnert H, Klein J, ;2010;The Journal of endocrinology;204;153-64; 19939912