MGI phenotypes (allele matching)
B6.129P2(SJL)-Gjd3tm2.1Kwi/Cnrm
| Status | Available to order |
| EMMA ID | EM:06026 |
| Citation information | RRID:IMSR_EM:06026 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2(SJL)-Gjd3tm2.1Kwi/Cnrm |
| Alternative name | Cx30.2YFP |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gjd3tm2.1Kwi |
| Gene/Transgene symbol | Gjd3 |
Information from provider
| Provider | Klaus Willecke |
| Provider affiliation | LIMES Institute, University of Bonn |
| Genetic information | The coding region of connexin 30.2 (Gjd3) was deleted and replaced by a YFP reporter gene. |
| Phenotypic information | Homozygous Cx30.2YFP mice show a faster impulse propagation through the atrioventricular node. |
| Breeding history | The line was backcrossed at least five times to C57BL/6 mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- no phenotypic analysis / MGI
- abnormal impulse conducting system conduction / MGI
- nervous system phenotype / MGI
- cardiovascular system phenotype / MGI
- abnormal atrioventricular node conduction / MGI
- abnormal heart electrocardiography waveform feature / MGI
- shortened PR interval / MGI
- mortality/aging / MGI
- shortened PQ interval / MGI
Literature references
- Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart.;Frank Marina, Wirth Angela, Andrié René P, Kreuzberg Maria M, Dobrowolski Radoslaw, Seifert Gerald, Offermanns Stefan, Nickenig Georg, Willecke Klaus, Schrickel Jan W, ;2012;Circulation research;111;1528-38; 22982984