B6.129P2(SJL)-Gjd3tm2.1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:06026 |
International strain name | B6.129P2(SJL)-Gjd3tm2.1Kwi/Cnrm |
Alternative name | Cx30.2YFP |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Gjd3tm2.1Kwi |
Gene/Transgene symbol | Gjd3 |
Information from provider
Provider | Klaus Willecke |
Provider affiliation | LIMES Institute, University of Bonn |
Genetic information | The coding region of connexin 30.2 (Gjd3) was deleted and replaced by a YFP reporter gene. |
Phenotypic information | Homozygous Cx30.2YFP mice show a faster impulse propagation through the atrioventricular node. |
Breeding history | The line was backcrossed at least five times to C57BL/6 mice. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- no phenotypic analysis / MGI
- abnormal impulse conducting system conduction / MGI
- nervous system phenotype / MGI
- cardiovascular system phenotype / MGI
- abnormal atrioventricular node conduction / MGI
- abnormal heart electrocardiography waveform feature / MGI
- shortened PR interval / MGI
- mortality/aging / MGI
- shortened PQ interval / MGI
Literature references
- Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart.;Frank Marina, Wirth Angela, Andrié René P, Kreuzberg Maria M, Dobrowolski Radoslaw, Seifert Gerald, Offermanns Stefan, Nickenig Georg, Willecke Klaus, Schrickel Jan W, ;2012;Circulation research;111;1528-38; 22982984
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