MGI phenotypes (gene matching)
B6;129P2-Nkx6-2tm2(cre)Ercs/Kctt
| Status | Available to order |
| EMMA ID | EM:06022 |
| Citation information | RRID:IMSR_EM:06022 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Nkx6-2tm2(cre)Ercs/Kctt |
| Alternative name | Nkx6.2tm2Ercs / Nkx6.2Cre |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nkx6-2tm2(cre)Ercs |
| Gene/Transgene symbol | Nkx6-2 |
Information from provider
| Provider | Elisabet Andersson |
| Provider affiliation | Dept. Comparative Medicine, KCTT, Karolinska Institutet |
| Genetic information | The entire coding region was replaced with a cassette containing Cre and neomycin. Cre is expressed from this allele under the control of the endogenous promoter. |
| Phenotypic information | Mice homozygous for the mutant alleles were born at Mendelian frequency and survived through adulthood. No abnormal phenotype was observed. Similar to Nkx6.2tm1(lacZ)Ercs: nervous system abnormal axon outgrowth: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve; abnormal vagus ganglion morphology: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve. Cellular abnormal axon outgrowth: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve. |
| Breeding history | Mixed, not congenic. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- NKX6-2-related autosomal recessive hypomyelinating leukodystrophy / Orphanet_527497
Literature references
- Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204
- Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.;Pattyn Alexandre, Vallstedt Anna, Dias Jose M, Sander Maike, Ericson Johan, ;2003;Development (Cambridge, England);130;4149-59; 12874134