- decreased hematocrit / MGI
- hypertension / MGI
- anemia / MGI
- reticulocytosis / MGI
- poikilocytosis / MGI
- microcytosis / MGI
- decreased hemoglobin content / MGI
- abnormal erythrocyte osmotic lysis / MGI
- increased spleen weight / MGI
- increased circulating bilirubin level / MGI
- decreased mean corpuscular hemoglobin / MGI
- increased mean corpuscular hemoglobin concentration / MGI
- increased systemic arterial diastolic blood pressure / MGI
- increased systemic arterial systolic blood pressure / MGI
- increased pulse pressure / MGI
B6.129-Add2tm1Feb/Cnrm
Status | Available to order |
EMMA ID | EM:00006 |
International strain name | B6.129-Add2tm1Feb/Cnrm |
Alternative name | Add2-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Add2tm1Feb |
Gene/Transgene symbol | Add2 |
Information from provider
Provider | Francisco E. Baralle |
Provider affiliation | ICGEB-Inter.Centre Genetic Engineering Biotechnology |
Genetic information | Replacement (deletion) of Add2 exons 7 to 13 by the neomycin resistance gene. |
Phenotypic information | Phenotype defects: spherocytic hereditary elliptocytosis (SHE), hypertension. |
Breeding history | Backcrossed to C57BL/6 (6 generations). |
References |
|
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- decreased hematocrit / MGI
- hypertension / MGI
- enlarged spleen / MGI
- abnormal cued conditioning behavior / MGI
- abnormal spatial learning / MGI
- abnormal contextual conditioning behavior / MGI
- reduced long term potentiation / MGI
- anemia / MGI
- impaired synaptic plasticity / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal erythrocyte morphology / MGI
- decreased mean corpuscular volume / MGI
- reticulocytosis / MGI
- anisopoikilocytosis / MGI
- poikilocytosis / MGI
- spherocytosis / MGI
- microcytosis / MGI
- decreased hemoglobin content / MGI
- enhanced paired-pulse facilitation / MGI
- increased post-tetanic potentiation / MGI
- abnormal erythrocyte physiology / MGI
- abnormal erythrocyte osmotic lysis / MGI
- increased spleen weight / MGI
- increased circulating bilirubin level / MGI
- decreased mean corpuscular hemoglobin / MGI
- increased mean corpuscular hemoglobin concentration / MGI
- increased systemic arterial diastolic blood pressure / MGI
- increased systemic arterial systolic blood pressure / MGI
- increased pulse pressure / MGI
- increased liver iron level / MGI
- increased spleen iron level / MGI
- increased kidney iron level / MGI
Literature references
- Mild spherocytic hereditary elliptocytosis and altered levels of alpha- and gamma-adducins in beta-adducin-deficient mice.;Muro A F, Marro M L, Gajović S, Porro F, Luzzatto L, Baralle F E, ;2000;Blood;95;3978-85; 10845937
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).