CD1.129-Nog^tm1Amc/Orl

Status	Available to order
EMMA ID	EM:05988
International strain name	CD1.129-Nog^tm1Amc/Orl
Alternative name	Nogtm1Amc
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Nog^tm1Amc
Gene/Transgene symbol	Nog

Information from provider

Provider	Przemko Tylzanowski
Provider affiliation	Development Growth and Regeneration, University of Leuven
Genetic information	Gene targeting generated a null allele by fusing the first 10 amino acids of coding sequence in-frame to the lacZ gene. The remainder of the coding sequence and some of the 3' flanking sequence of the gene were deleted.
Phenotypic information	The noggin null embryos have multiple defects including a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.
Breeding history	Backcrossed into CD1 background for more than 20 generations.
References	Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.;Brunet L J, McMahon J A, McMahon A P, Harland R M, ;1998;Science (New York, N.Y.);280;1455-7; 9603738 The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects.;Tylzanowski Przemko, Mebis Liese, Luyten Frank P, ;2006;Developmental dynamics : an official publication of the American Association of Anatomists;235;1599-607; 16598734
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.)

Disease and phenotype information

MGI allele-associated human disease models

esophageal atresia/tracheoesophageal fistula / DOID:0080171

Orphanet associated rare diseases, based on orthologous gene matching

Stapes ankylosis with broad thumbs and toes / Orphanet_140917
Multiple synostoses syndrome / Orphanet_3237
Brachydactyly type B2 / Orphanet_140908
Tarsal-carpal coalition syndrome / Orphanet_1412
Proximal symphalangism / Orphanet_3250

IMPC phenotypes (gene matching)

abnormal placenta morphology / IMPC
abnormal embryo turning / IMPC
small kidney / IMPC
abnormal snout morphology / IMPC
preweaning lethality, complete penetrance / IMPC
abnormal neural tube morphology / IMPC
abnormal neural tube closure / IMPC
edema / IMPC
abnormal vitelline vasculature morphology / IMPC
abnormal visceral yolk sac morphology / IMPC
abnormal optic vesicle formation / IMPC
embryonic growth retardation / IMPC
abnormal forebrain development / IMPC
abnormal pharyngeal arch morphology / IMPC
abnormal blood vessel morphology / IMPC
abnormal somite shape / IMPC
abnormal heart morphology / IMPC
abnormal caudal vertebrae morphology / IMPC
abnormal bone structure / IMPC
increased circulating alkaline phosphatase level / IMPC
abnormal kidney morphology / IMPC

MGI phenotypes (allele matching)

abnormal middle ear morphology / MGI
abnormal rib morphology / MGI
kinked tail / MGI
fused synovial joints / MGI
conductive hearing loss / MGI
abnormal middle ear ossicle morphology / MGI
abnormal stapes morphology / MGI
impaired hearing / MGI
abnormal styloid process morphology / MGI
small thoracic cage / MGI
increased or absent threshold for auditory brainstem response / MGI
kyphosis / MGI
abnormal axial skeleton morphology / MGI
hearing/vestibular/ear phenotype / MGI
small prostate gland ventral lobe / MGI
exencephaly / MGI
perinatal lethality / MGI
abnormal malleus morphology / MGI
fusion of middle ear ossicles / MGI
small limb buds / MGI
abnormal incus morphology / MGI
lethality throughout fetal growth and development, complete penetrance / MGI
abnormal craniofacial morphology / MGI
abnormal neural tube morphology / MGI
abnormal skeleton morphology / MGI
perinatal lethality, complete penetrance / MGI
short face / MGI
abnormal interparietal bone morphology / MGI
abnormal frontal bone morphology / MGI
abnormal parietal bone morphology / MGI
short limbs / MGI
incomplete rostral neuropore closure / MGI
open neural tube / MGI
wavy neural tube / MGI
abnormal spinal cord morphology / MGI
abnormal lung morphology / MGI
abnormal lung development / MGI
abnormal somite development / MGI
kinked neural tube / MGI
absent tail / MGI
abnormal neural tube closure / MGI
abnormal vertebral arch morphology / MGI
absent vertebral arch / MGI
abnormal occipital bone morphology / MGI
spina bifida occulta / MGI
abnormal neural plate morphology / MGI
increased apoptosis / MGI
abnormal right lung morphology / MGI
abnormal basicranium morphology / MGI
edema / MGI
abnormal muscle morphology / MGI
abnormal limb morphology / MGI
vestigial tail / MGI
abnormal bone mineralization / MGI
abnormal hair follicle development / MGI
abnormal muscle fiber morphology / MGI
decreased fetal size / MGI
abnormal limb bud morphology / MGI
hematoma / MGI
abnormal cochlea morphology / MGI
decreased cochlear coiling / MGI
increased cochlear inner hair cell number / MGI
increased cochlear outer hair cell number / MGI
abnormal eye development / MGI
decreased embryo size / MGI
abnormal notochord morphology / MGI
abnormal ear development / MGI
abnormal rostral-caudal patterning of the somites / MGI
decreased somite size / MGI
abnormal foregut morphology / MGI
abnormal esophagus development / MGI
esophageal atresia / MGI
tracheoesophageal fistula / MGI
esophagus stenosis / MGI
abnormal head morphology / MGI
abnormal diencephalon morphology / MGI
abnormal pituitary gland development / MGI
absent pituitary gland / MGI
abnormal pituitary gland physiology / MGI
absent adenohypophysis / MGI
absent Rathke's pouch / MGI
abnormal Rathke's pouch development / MGI
abnormal Rathke's pouch apoptosis / MGI
absent pituitary infundibular stalk / MGI
abnormal urethra morphology / MGI
abnormal male reproductive system morphology / MGI
abnormal prostate gland morphology / MGI
cryptorchism / MGI
absent bulbourethral gland / MGI
abnormal septation of the cloaca / MGI
anal atresia / MGI
abnormal urinary system development / MGI
abnormal prostate gland development / MGI
abnormal primitive urogenital sinus morphology / MGI
pelvic kidney / MGI

MGI phenotypes (gene matching)

abnormal malleus morphology / MGI
abnormal cochlea morphology / MGI
abnormal middle ear morphology / MGI
abnormal interparietal bone morphology / MGI
abnormal frontal bone morphology / MGI
abnormal parietal bone morphology / MGI
abnormal rib morphology / MGI
kyphosis / MGI
abnormal craniofacial morphology / MGI
abnormal head morphology / MGI
abnormal foregut morphology / MGI
abnormal urethra morphology / MGI
short limbs / MGI
kinked tail / MGI
small prostate gland ventral lobe / MGI
abnormal diencephalon morphology / MGI
exencephaly / MGI
incomplete rostral neuropore closure / MGI
open neural tube / MGI
wavy neural tube / MGI
abnormal spinal cord morphology / MGI
abnormal male reproductive system morphology / MGI
abnormal prostate gland morphology / MGI
abnormal lung morphology / MGI
abnormal lung development / MGI
abnormal eye development / MGI
abnormal somite development / MGI
decreased embryo size / MGI
edema / MGI
perinatal lethality / MGI
abnormal muscle morphology / MGI
abnormal limb morphology / MGI
abnormal axial skeleton morphology / MGI
abnormal neural tube morphology / MGI
cryptorchism / MGI
vestigial tail / MGI
absent bulbourethral gland / MGI
abnormal notochord morphology / MGI
abnormal bone mineralization / MGI
abnormal septation of the cloaca / MGI
anal atresia / MGI
decreased cochlear coiling / MGI
abnormal esophagus development / MGI
fused synovial joints / MGI
esophageal atresia / MGI
tracheoesophageal fistula / MGI
kinked neural tube / MGI
absent tail / MGI
abnormal hair follicle development / MGI
abnormal neural tube closure / MGI
fusion of middle ear ossicles / MGI
abnormal pituitary gland development / MGI
abnormal ear development / MGI
abnormal urinary system development / MGI
abnormal muscle fiber morphology / MGI
decreased fetal size / MGI
increased cochlear inner hair cell number / MGI
increased cochlear outer hair cell number / MGI
small limb buds / MGI
abnormal vertebral arch morphology / MGI
absent vertebral arch / MGI
conductive hearing loss / MGI
abnormal middle ear ossicle morphology / MGI
abnormal incus morphology / MGI
abnormal stapes morphology / MGI
abnormal occipital bone morphology / MGI
spina bifida occulta / MGI
absent pituitary gland / MGI
hearing/vestibular/ear phenotype / MGI
abnormal skeleton morphology / MGI
abnormal pituitary gland physiology / MGI
abnormal limb bud morphology / MGI
abnormal neural plate morphology / MGI
increased apoptosis / MGI
impaired hearing / MGI
abnormal styloid process morphology / MGI
absent adenohypophysis / MGI
abnormal rostral-caudal patterning of the somites / MGI
hematoma / MGI
abnormal right lung morphology / MGI
abnormal prostate gland development / MGI
abnormal basicranium morphology / MGI
small thoracic cage / MGI
abnormal primitive urogenital sinus morphology / MGI
esophagus stenosis / MGI
perinatal lethality, complete penetrance / MGI
lethality throughout fetal growth and development, complete penetrance / MGI
pelvic kidney / MGI
decreased somite size / MGI
absent Rathke's pouch / MGI
increased or absent threshold for auditory brainstem response / MGI
abnormal Rathke's pouch development / MGI
abnormal Rathke's pouch apoptosis / MGI
absent pituitary infundibular stalk / MGI
short face / MGI

Literature references

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.;Brunet L J, McMahon J A, McMahon A P, Harland R M, ;1998;Science (New York, N.Y.);280;1455-7; 9603738
The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects.;Tylzanowski Przemko, Mebis Liese, Luyten Frank P, ;2006;Developmental dynamics : an official publication of the American Association of Anatomists;235;1599-607; 16598734

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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CD1.129-Nogtm1Amc/Orl