C57BL/6N-Frs2tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:05929
International strain nameC57BL/6N-Frs2tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0471_4_B06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFrs2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolFrs2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0471_4_B06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal auditory brainstem response / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • microcephaly / MGI
  • decreased brain size / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal cerebellum development / MGI
  • abnormal cerebellar plate morphology / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • decreased embryo size / MGI
  • abnormal limb morphology / MGI
  • abnormal pharyngeal arch morphology / MGI
  • nervous system phenotype / MGI
  • embryonic growth retardation / MGI
  • decreased fetal size / MGI
  • abnormal embryonic/fetal subventricular zone morphology / MGI
  • abnormal trophoblast giant cell morphology / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • craniofacial phenotype / MGI
  • vision/eye phenotype / MGI
  • thin cerebral cortex / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal visceral endoderm morphology / MGI
  • abnormal primitive streak elongation / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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