IMPC phenotypes (gene matching)
C.129P2-Cx3cr1tm1Litt/Ieg
| Status | Available to order |
| EMMA ID | EM:00591 |
| Citation information | RRID:IMSR_EM:00591 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.129P2-Cx3cr1tm1Litt/Ieg |
| Alternative name | CX3CR1/GFP |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cx3cr1tm1Litt |
| Gene/Transgene symbol | Cx3cr1 |
Information from provider
| Provider | Steffen Jung |
| Provider affiliation | The Weizmann Institute of Science |
| Genetic information | The mutant mice carry a targeted replacement of the Cx3cr1 chemokine receptor gene with an EGFP reporter gene (see Jung et al. MCB 2000). |
| Phenotypic information | The mutant mice have no obvious defects. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
- paresis / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- microgliosis / MGI
- homeostasis/metabolism phenotype / MGI
- paralysis / MGI
- demyelination / MGI
- brain inflammation / MGI
- abnormal leukocyte physiology / MGI
- increased neuron apoptosis / MGI
- abnormal microglial cell physiology / MGI
- abnormal vascular wound healing / MGI
- immune system phenotype / MGI
- abnormal vascular smooth muscle physiology / MGI
- brainstem hemorrhage / MGI
- decreased NK cell number / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
- abnormal dendritic cell physiology / MGI
- abnormal small intestinal villus morphology / MGI
- increased dendritic cell number / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- decreased monocyte cell number / MGI
- abnormal retina morphology / MGI
- nervous system phenotype / MGI
- impaired macrophage chemotaxis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- choroidal neovascularization / MGI
MGI phenotypes (gene matching)
- decreased monocyte cell number / MGI
- paralysis / MGI
- paresis / MGI
- demyelination / MGI
- abnormal retina morphology / MGI
- retinal degeneration / MGI
- brain inflammation / MGI
- no abnormal phenotype detected / MGI
- abnormal dendritic cell physiology / MGI
- abnormal leukocyte physiology / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- nervous system phenotype / MGI
- abnormal microglial cell physiology / MGI
- abnormal retinal photoreceptor layer morphology / MGI
- impaired macrophage chemotaxis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- homeostasis/metabolism phenotype / MGI
- immune system phenotype / MGI
- choroidal neovascularization / MGI
- abnormal vascular smooth muscle physiology / MGI
- abnormal response to transplant / MGI
- brainstem hemorrhage / MGI
- retinal deposits / MGI
- decreased NK cell number / MGI
- abnormal small intestinal villus morphology / MGI
- increased dendritic cell number / MGI
- thin retinal outer nuclear layer / MGI
- microgliosis / MGI
- abnormal splenocyte physiology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
Literature references
- Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.;Jung S, Aliberti J, Graemmel P, Sunshine M J, Kreutzberg G W, Sher A, Littman D R, ;2000;Molecular and cellular biology;20;4106-14; 10805752
- Microglial Cx3cr1 knockout reduces prion disease incubation time in mice.;Grizenkova Julia, Akhtar Shaheen, Brandner Sebastian, Collinge John, Lloyd Sarah E, ;2014;BMC neuroscience;15;44; 24655482
- Vagus nerve stimulation dampens intestinal inflammation in a murine model of experimental food allergy.;Bosmans Goele, Appeltans Iris, Stakenborg Nathalie, Gomez-Pinilla Pedro J, Florens Morgane V, Aguilera-Lizarraga Javier, Matteoli Gianluca, Boeckxstaens Guy E, ;2019;Allergy;74;1748-1759; 30897213