IMPC phenotypes (gene matching)
C.129P2-Cx3cr1tm1Litt/Ieg
| Status | Available to order |
| EMMA ID | EM:00591 |
| International strain name | C.129P2-Cx3cr1tm1Litt/Ieg |
| Alternative name | CX3CR1/GFP |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cx3cr1tm1Litt |
| Gene/Transgene symbol | Cx3cr1 |
Information from provider
| Provider | Steffen Jung |
| Provider affiliation | The Weizmann Institute of Science |
| Genetic information | The mutant mice carry a targeted replacement of the Cx3cr1 chemokine receptor gene with an EGFP reporter gene (see Jung et al. MCB 2000). |
| Phenotypic information | The mutant mice have no obvious defects. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
- paresis / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- microgliosis / MGI
- homeostasis/metabolism phenotype / MGI
- paralysis / MGI
- demyelination / MGI
- brain inflammation / MGI
- abnormal leukocyte physiology / MGI
- increased neuron apoptosis / MGI
- abnormal microglial cell physiology / MGI
- abnormal vascular wound healing / MGI
- immune system phenotype / MGI
- abnormal vascular smooth muscle physiology / MGI
- brainstem hemorrhage / MGI
- decreased NK cell number / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
- abnormal dendritic cell physiology / MGI
- abnormal small intestinal villus morphology / MGI
- increased dendritic cell number / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- decreased monocyte cell number / MGI
- abnormal retina morphology / MGI
- nervous system phenotype / MGI
- impaired macrophage chemotaxis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- choroidal neovascularization / MGI
MGI phenotypes (gene matching)
- decreased monocyte cell number / MGI
- paralysis / MGI
- paresis / MGI
- demyelination / MGI
- abnormal retina morphology / MGI
- retinal degeneration / MGI
- brain inflammation / MGI
- no abnormal phenotype detected / MGI
- abnormal dendritic cell physiology / MGI
- abnormal leukocyte physiology / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- nervous system phenotype / MGI
- abnormal microglial cell physiology / MGI
- abnormal retinal photoreceptor layer morphology / MGI
- impaired macrophage chemotaxis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- homeostasis/metabolism phenotype / MGI
- immune system phenotype / MGI
- choroidal neovascularization / MGI
- abnormal vascular smooth muscle physiology / MGI
- abnormal response to transplant / MGI
- brainstem hemorrhage / MGI
- retinal deposits / MGI
- decreased NK cell number / MGI
- abnormal small intestinal villus morphology / MGI
- increased dendritic cell number / MGI
- thin retinal outer nuclear layer / MGI
- microgliosis / MGI
- abnormal splenocyte physiology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
Literature references
- Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.;Jung S, Aliberti J, Graemmel P, Sunshine M J, Kreutzberg G W, Sher A, Littman D R, ;2000;Molecular and cellular biology;20;4106-14; 10805752
- Microglial Cx3cr1 knockout reduces prion disease incubation time in mice.;Grizenkova Julia, Akhtar Shaheen, Brandner Sebastian, Collinge John, Lloyd Sarah E, ;2014;BMC neuroscience;15;44; 24655482
- Vagus nerve stimulation dampens intestinal inflammation in a murine model of experimental food allergy.;Bosmans Goele, Appeltans Iris, Stakenborg Nathalie, Gomez-Pinilla Pedro J, Florens Morgane V, Aguilera-Lizarraga Javier, Matteoli Gianluca, Boeckxstaens Guy E, ;2019;Allergy;74;1748-1759; 30897213