C57BL/6NTac-Plxnb2tm1a(EUCOMM)Wtsi/WtsiIeg

Status

Available to order

EMMA IDEM:05892
International strain nameC57BL/6NTac-Plxnb2tm1a(EUCOMM)Wtsi/WtsiIeg
Alternative nameEPD0051_2_A09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPlxnb2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolPlxnb2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0051_2_A09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal urination / IMPC
  • increased IgE level / IMPC
  • abnormal response to tactile stimuli / IMPC
IMPC phenotypes (gene matching)
  • increased IgE level / IMPC
  • abnormal urination / IMPC
  • abnormal response to tactile stimuli / IMPC
MGI phenotypes (allele matching)
  • belly spot / MGI
  • abnormal coat/hair pigmentation / MGI
MGI phenotypes (gene matching)
  • belly spot / MGI
  • abnormal choroid plexus morphology / MGI
  • abnormal brain ventricle morphology / MGI
  • abnormal diencephalon morphology / MGI
  • abnormal cerebellum morphology / MGI
  • small cerebellum / MGI
  • absent cerebellar foliation / MGI
  • abnormal cerebellar foliation / MGI
  • abnormal cerebellum external granule cell layer morphology / MGI
  • abnormal cerebellar Purkinje cell layer / MGI
  • ectopic Purkinje cell / MGI
  • abnormal cerebellar granule layer morphology / MGI
  • exencephaly / MGI
  • incomplete rostral neuropore closure / MGI
  • open neural tube / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal neural tube morphology / MGI
  • abnormal brain morphology / MGI
  • abnormal olfactory bulb development / MGI
  • ectopic cerebellar granule cells / MGI
  • small kidney / MGI
  • curly tail / MGI
  • spina bifida / MGI
  • renal hypoplasia / MGI
  • abnormal radial glial cell morphology / MGI
  • duplex kidney / MGI
  • abnormal striatum morphology / MGI
  • abnormal cerebellar cortex morphology / MGI
  • abnormal cerebellar granule cell morphology / MGI
  • abnormal rostral migratory stream morphology / MGI
  • impaired branching involved in ureteric bud morphogenesis / MGI
  • behavior/neurological phenotype / MGI
  • reproductive system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal neuronal migration / MGI
  • abnormal olfactory bulb interneuron morphology / MGI
  • abnormal olfactory bulb granule cell morphology / MGI
  • abnormal olfactory bulb periglomerular cell morphology / MGI
  • abnormal olfactory bulb layer morphology / MGI
  • abnormal olfactory bulb internal plexiform layer morphology / MGI
  • abnormal olfactory bulb mitral cell layer morphology / MGI
  • abnormal cerebellar granule cell migration / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • enlarged brain ventricles / MGI
  • double ureter / MGI
  • abnormal ureteric bud tip morphology / MGI
  • double kidney pelvis / MGI
  • incomplete caudal neuropore closure / MGI
  • decreased neuronal precursor proliferation / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).