C57BL/6NTac-Sirt2tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:05857
International strain nameC57BL/6NTac-Sirt2tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0013_1_G11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSirt2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSirt2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0013_1_G11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac
Breeding at archiving centreChimeras were mated to C57BL/6N Tac USA and maintained on this background thereafter.

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased heart weight / IMPC
  • increased circulating creatinine level / IMPC
IMPC phenotypes (gene matching)
  • increased circulating creatinine level / IMPC
  • increased heart weight / IMPC
MGI phenotypes (gene matching)
  • mammary gland hyperplasia / MGI
  • abnormal apoptosis / MGI
  • increased tumor incidence / MGI
  • increased B cell derived lymphoma incidence / MGI
  • altered tumor susceptibility / MGI
  • no abnormal phenotype detected / MGI
  • abnormal cell cycle / MGI
  • increased hepatocellular carcinoma incidence / MGI
  • nervous system phenotype / MGI
  • abnormal chromosome morphology / MGI
  • aneuploidy / MGI
  • abnormal mitosis / MGI
  • behavior/neurological phenotype / MGI
  • delayed cellular replicative senescence / MGI
  • increased lung tumor incidence / MGI
  • increased pancreas tumor incidence / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • increased gastrointestinal tumor incidence / MGI
  • increased mammary gland tumor incidence / MGI
  • increased stomach tumor incidence / MGI
  • increased prostate gland tumor incidence / MGI
  • decreased fibroblast proliferation / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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