- thin ventricular wall / MGI
- abnormal interventricular septum morphology / MGI
- double outlet right ventricle / MGI
- decreased cell proliferation / MGI
- diluted coat color / MGI
- belly spot / MGI
- abnormal hindlimb morphology / MGI
- kinked tail / MGI
- abnormal thyroid gland morphology / MGI
- abnormal thymus morphology / MGI
- abnormal myogenesis / MGI
- abnormal muscle development / MGI
- abnormal myotome development / MGI
- abnormal skeletal muscle morphology / MGI
- thin diaphragm muscle / MGI
- abnormal brain ventricle morphology / MGI
- abnormal lateral ventricle morphology / MGI
- abnormal hindbrain morphology / MGI
- exencephaly / MGI
- incomplete rostral neuropore closure / MGI
- open neural tube / MGI
- small embryonic telencephalon / MGI
- abnormal spinal cord morphology / MGI
- abnormal dorsal root ganglion morphology / MGI
- disorganized dorsal root ganglion / MGI
- absent skin pigmentation / MGI
- decreased body size / MGI
- cyanosis / MGI
- abnormal somite development / MGI
- failure to gastrulate / MGI
- decreased embryo size / MGI
- respiratory distress / MGI
- neoplasm / MGI
- abnormal coat/hair pigmentation / MGI
- abnormal limb morphology / MGI
- abnormal tail morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal thymus lobule morphology / MGI
- abnormal semicircular canal morphology / MGI
- delayed neural tube closure / MGI
- persistent truncus arteriosis / MGI
- abnormal pharyngeal arch artery morphology / MGI
- dilated heart left ventricle / MGI
- dilated heart right ventricle / MGI
- white spotting / MGI
- head spot / MGI
- variable body spotting / MGI
- abnormal neural crest cell migration / MGI
- small thyroid gland / MGI
- ectopic thymus / MGI
- no phenotypic analysis / MGI
- curly tail / MGI
- spina bifida / MGI
- abnormal muscle precursor cell migration / MGI
- decreased cochlear coiling / MGI
- nervous system phenotype / MGI
- abnormal midbrain development / MGI
- abnormal tongue muscle morphology / MGI
- retroesophageal right subclavian artery / MGI
- abnormal dermomyotome development / MGI
- abnormal myocardial fiber physiology / MGI
- abnormal bony labyrinth / MGI
- increased mitotic index / MGI
- abnormal neural fold elevation formation / MGI
- absent skeletal muscle / MGI
- absent ultimobranchial body / MGI
- absent coat pigmentation / MGI
- absent thyroid gland / MGI
- hearing/vestibular/ear phenotype / MGI
- embryo phenotype / MGI
- cardiovascular system phenotype / MGI
- vision/eye phenotype / MGI
- hypopigmentation / MGI
- decreased ventricle muscle contractility / MGI
- abnormal endolymphatic duct morphology / MGI
- abnormal otic vesicle development / MGI
- abnormal vena cava morphology / MGI
- abnormal vestibular saccule morphology / MGI
- abnormal utricle morphology / MGI
- abnormal cardiac outflow tract development / MGI
- congestive heart failure / MGI
- absent hypaxial muscle / MGI
- abnormal sixth pharyngeal arch artery morphology / MGI
- short endolymphatic duct / MGI
- abnormal ventral coat pigmentation / MGI
- absent dorsal root ganglion / MGI
- embryonic lethality / MGI
- caudal rachischisis / MGI
- abnormal tail hair pigmentation / MGI
- abnormal hind foot hair pigmentation / MGI
- variable depigmentation / MGI
- transverse fur striping / MGI
- ventricular septal defect / MGI
- muscular ventricular septal defect / MGI
- persistent right dorsal aorta / MGI
- common truncal valve / MGI
- patent tricuspid valve / MGI
- dilated pulmonary trunk / MGI
- thick interventricular septum / MGI
- integument phenotype / MGI
- postnatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased tail pigmentation / MGI
- abnormal diaphragm development / MGI
- spina bifida cystica / MGI
- increased embryonic neuroepithelium apoptosis / MGI
- abnormal common carotid artery morphology / MGI
- abnormal mammary line morphology / MGI
- abnormal mammary placode morphology / MGI
- abnormal embryo morphology / MGI
- abnormal hypoglossal cord morphology / MGI
B6.Cg-Pax3tm2.2(Pax3/7.1)Ins/Orl
Status | Available to order |
EMMA ID | EM:05846 |
International strain name | B6.Cg-Pax3tm2.2(Pax3/7.1)Ins/Orl |
Alternative name | B6.Pax3AmphiPax37/+ |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Pax3tm2.2(Pax3/7.1)Ins |
Gene/Transgene symbol | Pax3 |
Information from provider
Provider | Frederic RELAIX |
Provider affiliation | Groupe Myologie, UMR-S 787 - INSERM - UPMC-Paris VI - Institut de Myologie |
Genetic information | This line has been derived from the B6.Pax3Amphi37-ILZ/+ (EMMA ID EM:05827) in which the Amphioxus Pax3/7 cDNA followed by the IRESLacZ gene has been introduced in the Pax3 locus. To generate this line, B6.Pax3Amphi37-ILZ/+ have been crossed with a FLP-expressing line (removing the LacZ gene). Floxed and FRT flanked cassettes have been removed: one FRT and one loxP site remain in the genome. |
Phenotypic information | The heterozygous mice are viable, fertile and present a white belly spot. Homozygous lethality. |
Breeding history | Heterozygotes are viable and fertile. Homozygous lethality. Heterozygous males are crossed to C57BL/6 females. The line has been backcrossed to C57BL/6 background for at least 5 generations. |
References | None available |
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Craniofacial-deafness-hand syndrome / Orphanet_1529
- Waardenburg syndrome type 1 / Orphanet_894
- Waardenburg syndrome type 3 / Orphanet_896
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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