C57BL/6NTac-Dusp4tm1a(EUCOMM)Wtsi/WtsiOrl

Status

Available to order

EMMA IDEM:05795
Citation informationRRID:IMSR_EM:05795 

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International strain nameC57BL/6NTac-Dusp4tm1a(EUCOMM)Wtsi/WtsiOrl
Alternative nameEPD0105_5_C02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolDusp4tm1a(EUCOMM)Wtsi
Gene/Transgene symbolDusp4
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0105_5_C02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating chloride level / IMPC
  • decreased circulating glucose level / IMPC
  • decreased circulating potassium level / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating glucose level / IMPC
  • decreased circulating chloride level / IMPC
  • decreased circulating potassium level / IMPC
MGI phenotypes (allele matching)
  • decreased caudal vertebrae number / MGI
  • decreased rib number / MGI
  • decreased lumbar vertebrae number / MGI
  • decreased thoracic vertebrae number / MGI
  • decreased circulating glucose level / MGI
  • decreased circulating potassium level / MGI
  • increased circulating sodium level / MGI
  • decreased circulating sodium level / MGI
  • increased sacral vertebrae number / MGI
MGI phenotypes (gene matching)
  • decreased caudal vertebrae number / MGI
  • abnormal macrophage physiology / MGI
  • decreased rib number / MGI
  • decreased lumbar vertebrae number / MGI
  • decreased thoracic vertebrae number / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased T cell proliferation / MGI
  • immune system phenotype / MGI
  • decreased circulating glucose level / MGI
  • decreased circulating potassium level / MGI
  • increased circulating sodium level / MGI
  • decreased circulating sodium level / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased IgG2a level / MGI
  • increased IgG1 level / MGI
  • increased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased interleukin-10 secretion / MGI
  • decreased interleukin-10 secretion / MGI
  • increased interleukin-12 secretion / MGI
  • increased interleukin-13 secretion / MGI
  • increased interleukin-4 secretion / MGI
  • increased interleukin-6 secretion / MGI
  • decreased B cell apoptosis / MGI
  • increased sacral vertebrae number / MGI

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Availabilities

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Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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